乙醇脱氢酶1B基因变异与高甘油三酯血症对早发冠心病的影响

目的探讨乙醇脱氢酶（ADH）1B基因变异（ADH1B*1/2）与高甘油三酯血症（HTG）交互作用对早发冠心病的影响。方法采用以医院为基础的病例对照研究方法,选择新诊断的冠心病患者为研究对象;男性55岁及55岁以前和女性65岁及65岁以前患冠心病为早发冠心病,男性55岁以后和女性65岁以后患冠心病为迟发冠心病。以167例早发冠心病患者为病例组,以235例迟发冠心病患者为对照组。TG>2.26?mmol/L为高甘油三酯血症;运用PCR-限制性片段长度多态性检测ADH1B*1/2基因变异;用多元Logistic回归调整潜在的混杂因素及估计比值比（OR）。用相加模型分析ADH1B*1/2基因变异与HTG间交互作用。结果ADH1B*1/2基因变异与HTG之间对早发冠心病具有正交互作用,协同效应指数（S）为1.72;交互效应超额相对危险度（RERI）为1.78;归因交互效应百分比（AP）为33.77％。用多元Logistic回归调整性别、吸烟指数、饮酒指数、体重指数、总胆固醇及舒张压后,ADH1B*1/2基因变异与HTG之间对早发冠心病仍具有正交互作用。调整上述混杂因素后,S为2.96;RERI为3.01;AP为54.29％。结论ADH1B*1/2基因变异与HTG在早发冠心病的患病中存在明显的正相加模型交互作用,使早发冠心病患病危险性增加约3倍;ADH1B*1/2基因变异与HTG同时存在时,在早发冠心病患病危险性中约54％是由两者交互作用所导致。

Interaction between polymorphism in the ADH1B gene and hypertriglyceridemia in premature coronary artery disease

Objective To assess the interaction between the ADH1B*1/2 polymorphism and hypertriglyceridemia(HTG) in premature coronary artery disease(p-CAD).Methods A hospital-based case-control study was conducted.Newly diagnosed CAD patients were recruited as the subjects.The 167 CAD patients diagnosed before or at 55 years old for males and 65 years old for females were assigned as the p-CAD,i.e.the case group;the other 235 late-onset CAD patients served as the control group.TG over 2.26 mmol/L was defined as hypert...