Spinal anesthesia and ephedrine in pregnant monkeys |
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| Authors: | M Eng P U Berges J T Parer J J Bonica K Ueland |
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| Institution: | 1. Department of Anesthesiology University of Washington, Seattle, Washington, USA;2. Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA;3. Regional Primate Research Center, University of Washington, Seattle, Washington, USA |
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| Abstract: | A study of the maternal and fetal effects of spinal hypotension and its treatment with ephedrine was made in 6 pregnant monkeys whose activity was controlled with succinylcholine and nitrous oxide. During spinal hypotension, mean maternal arterial blood pressure decreased 54 per cent; cardiac output, 18 per cent; total peripheral resistance, 47 per cent; and uterine blood flow, 30 per cent. Fetal PO2 decreased from a mean of 27.1 ± 6.4 to 15.4 ± 7.8. Fetal pH decreased from a mean of 7.34 ± 0.04 to 7.22 ± 0.05, and fetal PCO2 increased from 41.6 ± 6.1 to 50.9 ± 10.4 mm. Hg. Ephedrine was effective in restoring these changes in the maternal cardiovascular system toward prespinal levels and preventing further deterioration of the fetus. |
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| Keywords: | Reprint requests: Dr Marlene Eng Dept of Anesthesiology University of Washington Seattle Washington 98195 |
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