Clozapine for treatment-resistant agitation in dementia |
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Authors: | Lee Hochang B Hanner Jennifer A Yokley Jessica L Appleby Brian Hurowitz Lisa Lyketsos Constantine G |
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Affiliation: | Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA. hochang@jhmi.edu |
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Abstract: | Few studies have examined the potential role of clozapine in treatment of agitation in dementia patients who have previously failed to respond to standard pharmacotherapy. We conducted a systematic chart review of all elderly patients admitted to our inpatient unit between 2001 and 2004. Of them, 16 dementia patients were treated with clozapine for treatment-resistant agitation, and their charts were blindly rated by 3 clinicians on the Clinical Global Impression (CGI) Scale, Brief Agitation Rating Scale (BARS), and the Cohen-Mansfield Agitation Inventory-Short Form (CMAI-SF). Overall, clozapine therapy seemed beneficial in treatment-resistant agitation in dementia patients. |
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