| 龙葵总碱对肿瘤细胞膜钠泵及钙泵活性影响的研究 |
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| 引用本文： | 季宇彬,高世勇,王宏亮,邹翔. 龙葵总碱对肿瘤细胞膜钠泵及钙泵活性影响的研究[J]. 世界科学技术, 2006, 8(4): 40-43 |
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| 作者姓名： | 季宇彬 高世勇 王宏亮 邹翔 |
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| 作者单位： | [1]哈尔滨商业大学生命科学与环境科学研究中心,哈尔滨150076 [2]哈尔滨商业大学药物研究所博士后科研工作站,哈尔滨150076 |
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| 基金项目： | 国家自然科学基金;黑龙江省自然科学基金 |
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| 摘 要： | 目的：观察龙葵总碱对S180小鼠及H22小鼠肿瘤细胞膜Na^＋，K^＋-ATPase及Ca^＋＋，Mg^＋＋-ATPase活性的影响。方法：荷瘤小鼠分为治疗组（高剂量、中剂量、低剂量）和对照组（生理盐水组、环磷酰胺组），分别测定各组肿瘤细胞膜的Na^＋，K^＋ ATPase及Ca^＋＋，Mg^＋＋ -ATPase活性。结果：龙葵总碱对S180小鼠及H22小鼠肿瘤细胞膜Na^＋，K^＋ -ATPase及Ca^＋＋，Mg^＋＋ -ATPase活性均有明显的抑制作用，并且其抑制作用呈量效正相关。结论：龙葵总碱这一作用可能是其抗肿瘤作用机理之一。关键词：龙葵总碱肿瘤细胞膜钠泵钙泵
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| 关 键 词： | 龙葵总碱 肿瘤细胞膜 钠泵 钙泵 |
| 收稿时间： | 2006-02-20 |
| 修稿时间： | 2006-08-15 |
The effect Effect of Total Alkaloids from Solanum nigrum on activities Activities of Na+,K+-ATPase and Ca++,Mg++-ATPase in tumor Tumor cell Cell membranceMembrance |
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| Ji Yubing,Gao Shiyong,Wang Hongliang,Zou Xiang. The effect Effect of Total Alkaloids from Solanum nigrum on activities Activities of Na+,K+-ATPase and Ca++,Mg++-ATPase in tumor Tumor cell Cell membranceMembrance[J]. World Science and Technology(Modernization of Traditional Chinese Medicine), 2006, 8(4): 40-43 |
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| Authors: | Ji Yubing Gao Shiyong Wang Hongliang Zou Xiang |
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| Affiliation: | 1.Research Center of Research and Development on Life Sciences and Environmental Sciences, Harbin Commercial University of Commerce ,Harbin,150076;2.Postdoctoral Programme Work Station, the Institute of Materia-medico, of Harbin Commercial University, Harbin, 150076, China |
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| Abstract: | Objective:To observe the effect of total alkaloids (TA) from Solarium nigrum on the activities of Na+,K+-ATPase and Ca++,Mg++-ATPase in tumor cells'membrance of S180 and H22 mice. Methods: Mice were divided into treated group (high, medium and low dosage) and control group (normal saline and cyclophosphamide), and the activities of Na+,K+-ATPase and Ca++,Mg++-ATPase in tumor cells'membrance were examined measured respectively. Results:TA showed pronounced inhibition on the activities of Na+,K+-ATPase and Ca++,Mg++-ATPase at in tumor cells'membrance, and it showedand the inhibition showed dose-effect positive relationship. Conclusion: This effect may be one of the mechanisms of its antitumor effect. |
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| Keywords: | Ttotal alkaloids from Solanum nigrum(TA) Ttumor cell membrance Na+ K+-ATPase Ca++ Mg++-ATPase |
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