Evolution of QRS duration after myocardial infarction: clinical consequences

The natural history of late potentials after acute myocardial infarction (AMI) has been studied in the first 2 years following myocardial infarction (MI). The purpose of the study was to assess the influence of some time delays since MI, including a time delay longer than 2 years on signal-averaged ECG (SAECG). SAECG was recorded at 40-Hz high pass filtering in 40 patients 10 days after acute MI (SAECG 1), then repeated 6-12 months later (mean 9 +/- 3 months) (SAECG 2), and then, 2-4 years later (mean 3 +/- 2 years) (SAECG 3). QRS duration, root mean square voltage of the last 40 ms of QRS (RMS 40), and low amplitude signal duration (LAS) were measured at the first (1), second (2), and third recording (3). Results: (***P < 0.001) [table: see text] The analysis of individual results showed a lengthening QRS duration at the third recording only in patients who had a decreased left ventricular ejection fraction (LVEF) at the third recording. In 12 patients with LVEF > 40%, QRS duration did not change at the first and third recording (104 +/- 15 vs 101 +/- 12 ms). In all 28 patients, but one with LVEF < 40%, QRS duration increased from 107 +/- 12 to 128 +/- 18 ms***. There was no correlation between QRS duration and LVEF at the second recording and no correlation between QRS duration increase at the third recording and the presence or not of late potentials at the first recording. QRS duration lengthening at the third recording was significantly correlated with a left ventricular (LV) dilatation occurrence at the two-dimensional echocardiogram. All arrhythmic events, but two, occurred in patients who developed a QRS duration prolongation and were significantly correlated (P < 0.01) to a mean longer QRS duration (132 +/- 20 ms) than in patients without arrhythmic events (113 +/- 17 ms). In conclusion, the patients with a LV impairment, and who developed a LV dilatation several months after AMI, presented a delayed lengthening of QRS duration noted only at least 2 years after infarction. These patients are at risk of arrhythmic events.