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Transplantation of Cultured Human Neural Progenitor Cells into Rat Brain: Migration and Differentiation |
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| Authors: | M. A. Aleksandrova R. A. Poltavtseva M. V. Marei A. V. Revishchin I. N. Saburina I. V. Dubrovina L. I. Korochkin G. T. Sukhikh |
| Affiliation: | (1) N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Russia;(2) Institute of Biological Medicine, Moscow |
| Abstract: | We studied the fate in vitro cultured human stem/progenitor cells after transplantation into rat brain. The cells from human fetuses at 8-12 weeks' gestation were cultured in vitro for 14 days and transplanted into the brain of 10-day-old and adult rats. Microscopic examination showed that human stem/progenitor cells migrated into various regions of rat brain. Immunohistochemical assay demonstrated that some cells differentiated into astrocytes and neurons, while others retained the embryonic phenotype. |
| Keywords: | human neural stem/progenitor cells cultured cells transplantation differentiation |
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