女性抑郁症认知功能及临床特点

目的研究女性抑郁症患者认知功能的特点及认知功能与疗效间的关系。方法纳入符合入选及排除标准的女性抑郁症患者143例，于基线时及抗抑郁剂治疗6周后进行汉密尔顿抑郁量表-17项评分及认知功能测验，包括汉诺塔、连线测验、韦氏智力测验（成人）、语言流畅性、威斯康星卡片测验。结果抑郁症患者存在认知功能损害，经6周抗抑郁治疗后，疗效好组认知功能大多数指标恢复正常，连线测试各项指标均有显著性差异（t值分别为14．779、12．113、12．113、15．333、2．747、2．036，均P〈0．01）。WCST各项指标、语言流畅总数明显改善（t值分别为-5．690、15．351、21．547、2．142、-18．251，均P〈0．05），TOH计划时间、执行时间、总分有显著改善（t值分别为4．256，2．048，均P〈0．05），疗效差组大多数指标仍低于正常。结论女性抑郁症与正常女性在认知功能方面存在差异，经过抗抑郁治疗后认知功能得到部分改善，且疗效好组改善较疗效差组改善更明显，两组认知功能各项指标与病程均无相关性，与年龄呈负相关。

Cognitive function and clinical features of female patients with depression

Objective To study the cognitive function and clinical features of female patients with depression and their relationship with curative effect. Methods Altogether 143 female depression patients were recruited according to including and excluding criteria. They were evaluated with HAMD-17 and got cognitive function test at baseline check and 6 weeks after anti-depression treatment, including TOH, trail making test, WAIS-RC, language fluency and WCST. Results There was cognitive injury in female depression patients. After 6 weeks of treatment the cognitive function of most cases in more efficient group recovered, and there were significant differences in each index of trial making test （t value was 14. 779, 12.113, 12.113, 15. 333, 2.747 and 2. 036, respectively, all P 〈 0.01 ）. Each index of WCST and language frequency were improved remarkably （t value was -5. 690, 15. 351, 21. 547, 2. 142 and -18. 251, respectively, all P 〈 0.05）, and so were planning time, performing time and total score of TOH （t value was 4. 256 and 2. 048, respectively, both P 〈 0.05）. But most of indexes in less efficient group were lower than normal values. Conclusion There is difference in cognitive function between female depression patients and normal females. After anti-depression treatment cognitive function is partially improved, and the cognitive function in more efficient group is improved more obviously than that in less efficient group. Indexes of cognitive function are not correlated with course of disease, but they are negatively related with age.