血浆同型半胱氨酸水平检测对原发性高血压患者患冠心病的诊断价值

【目的】探讨血浆同型半胱氨酸（Homocysteine ，Hcy）水平检测对原发性高血压（Essential hyperten-sion ，ES）患者患冠心病的诊断价值。【方法】从2011年5月至2013年4月，对本院173例确诊为ES病患者进行冠脉造影检查。由冠脉造影检查结果分为高血压组（A组，76例）和高血压与冠心病并发组（B组，97例）；检测两组患者的 Hcy水平并进行分析比较。另外以血浆内 Hcy含量15μmol/L为分界值，比较不同Hcy水平患者发生冠心病的概率。【结果】通过Hcy水平比较发现B组患者 Hcy水平为（21．1±7．9）μmol/L ，明显高于A组（14．0±4．5）μmol/L ，且两组相比较差异有显著性（ P＜0．05）。另外以血浆内Hcy含量15μmol/L为分界值，得出Hcy正常组患冠心病概率为35．1％，比Hcy偏高组患冠心病概率67．7％明显更低，且两组相比较差异有显著性（ P＜0．05）。【结论】Hcy水平检测对ES发展为冠心病的概率具有一定的预测价值。

Value of Plasma Homocysteine in the Diagnosis of Coronary Heart Disease in Patients with Es-sential Hypertension

[Objective] To explore the value of plasma homocysteine （Hcy） in the diagnosis of coronary heart dis-ease in patients with essential hypertension （ES） .[Methods] A total of 173 patients diagnosed as ES in our hospital from May 2011 to April 2013 underwent coronary angiography examination .According to coronary angiography ex-amination results ,all patients were divided into hypertension group （group A ,n =76） and hypertension combined with coronary heart disease group （group B ,n=97） .The levels of Hcy in two groups were measured and compared . When plasma Hcy （15μmol/L ） was taken as the cut-off value ,the probability of coronary heart disease in patients with different level of Hcy was compared .[Results]The level of Hcy in group B was 21 .1 ± 7 .9？mol/L ,which was obviously higher than that in group A （14 .0 ± 4 .5μmol/L） ,and there was significant difference between two groups （ P 〈0 .05） .When plasma Hcy（15μmol/L） was taken as the cut-off value ,the probability of coronary heart disease in patients with normal Hcy was 35 .1% ,which was obviously lower than that in high Hcy group （67 .7% ） ,and there was significant difference between two groups （ P〈0 .05） .[Conclusion]Hcy level is valuable for predicting the probability of ES developing to coronary heart disease .