生长激素在体外授精-胚胎移植卵巢低反应患者中的应用

【目的】探讨重组人生长激素（GH ）对卵巢储备功能低下患者体外授精‐胚胎移植（IVF‐ET ）的作用。【方法】收集行IVF‐ET的卵巢储备功能低下不孕患者78例，根据患者意愿分为两组：GH组36例（GH组），采用超长方案，同时加用GH ；对照组42例，仅采用超长方案。比较两组超排卵过程及妊娠结局。【结果】 G H组促性腺激素（Gn）用量及Gn使用时间显著低于对照组；GH组临床妊娠率高于对照组，流产率低于对照组，其差异均有统计学意义（ P＜0．05）。【结论】GH对卵巢储备功能低下患者可减少 Gn使用量，改善卵子质量，提高临床妊娠率。

Application of Growth Hormone in Patients with Poor Ovarian Response after in-vitro Fertilization-embryo Transfer

[Objective]To explore the effect of recombinant human growth hormone （GH） on in‐vitro fertilization‐em‐bryo transfer（IVF‐ET） in patients with poor ovarian reserve function .[Methods]A total of 78 infertile patients with poor ovarian reserve receiving IVF‐ET were collected .According to patients＆#39;will ,all patients were divided into two groups . GH group（ n=36） received ultra‐long scheme combined with GH ,while the control group（ n=42） only received ultra‐long scheme .Superovulation process and pregnancy outcome were compared between two groups .[Results]The dose and duration of gonadotropin（Gn） in GH group were markedly lower than those in control group ,while clinical pregnancy rate was higher and the abortion rate was lower in GH group than those in control group ,and there were significant differences （ P〈0 .05） .[Conclusion]GH therapy for the patients with poor ovarian reserve can reduce the dose of Gn ,improve the quality of oocytes and increase the clinical pregnancy rate .