2型糖尿病患者颈动脉内膜-中层厚度与血清白介素-6及超敏C 反应蛋白的关系研究 |
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引用本文: | 韩玲玲,张晓蕾,王玉霞,尚晓菁.2型糖尿病患者颈动脉内膜-中层厚度与血清白介素-6及超敏C 反应蛋白的关系研究[J].湖南医学,2014(4):646-648. |
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作者姓名: | 韩玲玲 张晓蕾 王玉霞 尚晓菁 |
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作者单位: | 中国医科大学附属第四医院内分泌科,辽宁沈阳110032 |
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基金项目: | 辽宁省科技厅资助项目(2012225019) |
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摘 要: | 【目的】探讨2型糖尿病(T2DM)患者颈动脉内膜-中层厚度(IMT)与白介素-6(IL-6)及血清超敏反应蛋白(hs-CRP)的关系。【方法】选取新确诊的T2DM患者201例,按IMT分为IMT增厚组(IMT>0.9 mm)99例及IM T正常组(IM T<0.9 mm )102例,均采集空腹血标本,测定血清IL-6及hs-CRP。使用彩色多普勒测定各组受试者的颈动脉IM T。【结果】①在T2DM 受试者中,IM T增厚组IL-6及hs-CRP水平均显著高于IM T 正常组( P <0.01)。②在IM T增厚组,IL-6及hs-CRP均与IM T呈正相关( r分别为0.73和0.78,P<0.01),在IM T正常组,IL-6及hs-CRP与IM T亦呈正相关( r分别为0.62和0.59,P <0.01);将 T2DM 患者作为一个整体, IL-6与hs-CRP也存在相关性( r为0.66,P <0.01)。【结论】IL-6及hs-CRP与 T2DM 患者早期动脉粥样硬化有密切的关系。
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关 键 词: | 糖尿病 2型 颈动脉 白细胞介素6 C反应蛋白质 |
Study on the Relationship of Carotid Intima-media Thickness with Serum Interleukin-6 and High-sensitive C-reactive Protein in Patients with Type 2 Diabetes Mellitus |
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Institution: | HAN ling-ling, ZHANG Xiao-lei, WANG Yu-xia ,et al ( Department of Endocrinology, the Forth Affiliated Hospital of China Medical University, Shenyang 110032, China ) |
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Abstract: | Objective]To explore the relationship of carotid intima-media thickness (IM T ) with serum inter-leukin-6(IL-6) and high-sensitive C-reactive protein(hs-CRP) in patients with type 2 diabetes mellitus(T2DM) .Methods]Totally 201 patients with newly diagnosed T2DM were selected .According to carotid IMT ,all patients were divided into IMT increased group(IMT〉0 .9mm ,n=99) and normal IMT group(IMT〈0 .9mm ,n=102) . Fast blood samples were collected .Serum levels of IL-6 and hs-CRP were measured .Carotid IMT of the subjects in each group was detected by using color Doppler apparatus .Results] Among T2DM subjects ,the levels of IL-6 and hs-CRP in IMT increased group were significantly higher than those in normal IMT group ( P 〈 0 .01) .In IMT increased group ,IL-6 and hs-CRP were positively correlated with IMT (r was 0 .73 and 0 .78 respectively ,P〈0 .01) .In normal IM T group ,IL-6 and hs-CRP were also positively correlated with IM T (r was 0 .62 and 0 .59 respectively ,P 〈0 .01) .If T2DM patients were considered as the whole ,IL-6 was also related with hs-CRP(r was 0 .66 ,P 〈0 .01) .Conclusion] IL-6 and hs-CRP are closely related with early atherosclerosis of T 2DM pa-tients . |
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Keywords: | Diabetes Mellitus Type 2 Carotid Arteries Interleukin-6 C-Reactive Protein |
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