改良拮抗剂方案促排卵治疗后冻融胚胎移植与新鲜胚胎移植的临床结局比较

【目的】探讨改良拮抗剂方案促排卵治疗后冻融胚胎移植的临床结局是否优于新鲜胚胎移植。【方法】回顾性分析本中心2012年6～9月采用改良拮抗剂方案促排卵后将全胚冷冻后再行冻融胚胎移植的患者（冻胚组，68例）与当周期行新胚移植（鲜胚组，82例）的临床结局。【结果】冻胚组胚胎着床率、临床妊娠率分别为43．38％、66．17％，较鲜胚组胚胎着床率（30．98％）、临床妊娠率（42．68％）明显升高（P〈0．05），而其流产率（8．89％VS11．43％）和多胎妊娠率（31．1％VS34．3％）比较差异均无显著性（均P〉0．05）。【结论】改良拮抗剂方案促排卵治疗中将全胚冷冻保存后再行冻融胚胎移植可以大大地提高临床妊娠率。

Comparison of Clinical Outcome Between Frozen-thawed Embryo Transfer and Fresh Embryo Transfer after the Improved Protocol of Antagonist for Ovarian Stimulation

[Objective]To explore whether clinical outcome of frozen-thawed embryo transfer after the improved protocol of antagonist for ovarian stimulation is better than that of fresh embryo transfer. [Methods] Clinical outcomes of 68 patients undergoing frozen-thawed embryo transfer following total embryo cryopreservation after the improved protocol of antagonist for ovarian ＇stimulation（ frozen-thawed embryo group） and 82 concurrent patients undergoing fresh embryo transfer（fresh embryo group） in our center from June 2012 to Sept. 2012 were analyzed retrospectively. [Results] The implantation rate and clinical pregnancy rate in frozen-thawed embryo group were 43. 38% and 66. 17 % respectively, which were obviously higher than those in fresh embryo group（30.98% and 42.68%, respectively）（ P〈0.05）. There was no significant difference in the abortion rate（8.89% vs. 11.43%） and multiple pregnancy rate（31.1%vs. 34. 3%） between two groups（all P 〉0.05）. [Conclusion] Frozenthawed embryo transfer following total embryo cryopreservation in the improved protocol of antagonist for ovarian stimulation can greatly improve the clinical pregnancy rate.