三联疗法治疗急性肺栓塞的临床效果观察

目的探讨三联疗法治疗急性肺栓塞的临床效果，以期为临床推广作指导。方法选择本院2010年1月-2013年1月收治的73例急性肺栓塞患者为研究对象，随机分为观察组和对照组。观察组采用三联疗法（尿激酶、低分子肝素、华法林）治疗，对照组采用重组组织型纤溶酶原激活剂联合低分子肝素治疗，比较两组治疗前后的PaO2、PaCO2，治疗后的总有效率及并发症发生率。结果两组治疗后PaO2明显升高、PaCO2明显降低，且观察组明显优于对照组，差异有统计学意义（P〈O．05）；观察组总有效率为94．59％，明显高于对照组的77．78％，差异有统计学意义（P〈0．05）；观察组并发症发生率为8．11％，明显低于对照组的19．44％，差异有统计学意义（P〈O．05）。结论三联疗法治疗急性肺栓塞的效果显著，且副作用小，值得临床推广。

Clinical efficacy observation of triple therapies in the treatment of acute pulmonary embolism

Objective To investigate clinical efficacy of triple therapies in the treatment of acute pulmonary embolism in order to guide clinical promotion.Methods 73 cases with acute pulmonary embolism patients in our hospital from January 2010 to January 2013 were divided into observation group and control group.Triple therapies（urokinase,low molecular weight heparin and warfarin） were used in observation group,recombinant tissue-type plasminogen activator and low molecular weight heparin were used in control group.PaO2,PaCO2 before and after treatment,total effective rate and incidence rate of complication after treatment in two groups were compared.Results PaO2 significantly increased and PaCO2 significantly decreased in two groups after treatment,observation group was better than control group,with statistical difference （P〈0.05）.Total effective rate of observation group was 94.59%,significantly higher than that of con- trol group （77.78%）,with statistical difference （P〈0.OS）.Ineidenee rate of complication in observation group was 8.11%, significantly lower than that of control group （19.44%）,with statistical difference （P〈0.05）.Conclusion Triple therapies have significant effect in the treatment of acute pulmonary embolism,it is worthy of clinical promotion.