诱生型一氧化氮合酶及一氧化氮对心脏的作用

目的介绍诱生型一氧化氮合酶(iNOs)介导的一氧化氮在心脏中的作用的研究进展。方法采用文献回顾的方式对国内外相关文献进行分析整理,对一氧化氮合酶的结构功能、一氧化氮在心脏中的作用的方式进行综述。结果iNOs介导的一氧化氮在心脏中的表达是导致心脏功能障碍的重要原因,iNOs的表达对心脏功能有保护和损伤两个方面的争论。结论iNOs在心脏中保护和损伤双重作用主要取决于分泌方式、一氧化氮浓度以及信号传导方式。

Role of inducible nitric oxide synthase and nitric oxide in heart

Objective To introduce the research progression on role of nitric oxide (NO) in heart mediated by inducible nitric oxide synthase(iNOs).Methods The data about these aspects in domestic and foreign in past years were retrospective analysis ,and the structure,function and effect modalities of nitric oxide (NO) in heart were summaried.Results Nitric oxide (NO)mediated by inducible nitric oxide synthase (iNOs)plays an crucial role in cardiac dysfunction .The roles of iNOs with protection or damage in heart were disputed.Conclusion The bidirection effects of iNOs,protective and damage effects for heart depend on secretion styles ,concentration and signaling modalities of NO.