Fas和FasL在乳腺癌中表达及临床意义

目的:研究Fas蛋白(CD95/Apol21,Fas)、Fas配体(Fasligand,FasL)在乳腺癌组织中的表达,并探讨其与淋巴结转移的关系。方法:采用免疫组化LSAB法检测50例乳腺癌组织Fas和FasL的表达。结果:Fas及FasL在乳腺癌组织中的阳性表达率分别为38和82。乳腺癌组织FasL的阳性表达率明显高于正常组织(P<0.05),Fas明显低于正常组织(P<0.05)。Fas的表达与淋巴结转移有关(P<0.05)。结论:Fas及FasL的表达与乳腺癌的临床特征和预后有关。

The expression and clinical significance of Fas and FasL in human breast carcinoma

Objective:To study the expression of Fas and FasL in human breast carcinoma,explore the relationship between the expression levels and lymphatic metastasis.Methods:Immunohistochemistry LSAB method was used to detect the expression of Fas and FasL in 50 breast carcinoma tissues and 12 normal breast tissues.Results:The expression of Fas and FasL had significant difference between breast carcinoma tissues and normal breast tissues(P<0.05).The positive expression rates of Fas and FasL were 38% and 82%,respectively.The positive expression rate of FasL in breast carcinoma was significantly higher than that in normal tissues(P<0.05),while the positive expression rate of Fas was significantly lower than that in normal tissues(P<0.05).Lymphatic metastasis was effected by the expression of Fas(P<0.05).Conclusion:The abnormal expression of Fas and FasL are related to clinical features and prognosis of human breast carcinoma.