| PTEN在膀胱癌组织中的表达及其意义 |
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| 引用本文： | 张建华,杨为民,周四维. PTEN在膀胱癌组织中的表达及其意义[J]. 中德临床肿瘤学杂志, 2005, 4(4): 218-220. DOI: 10.1007/s10330-004-0282-4 |
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| 作者姓名： | 张建华 杨为民 周四维 |
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| 作者单位： | 武汉华中科技大学同济医学院附属同济医院泌尿外科 430030(张建华，杨为民)，武汉华中科技大学同济医学院附属同济医院泌尿外科 430030(周四维) |
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| 摘 要： | 目的研究膀胱癌组织中抑癌基因PTEN的表达及其临床意义,评价FTEN在膀胱癌发生发展中的作用。方法应用免疫组织化学S-P法检测62例膀胱癌组织和18例良性膀胱病变组织中PTEN的表达,同时结合相关临床因素进行分析。结果62例膀胱癌组织中PTEN阳性率为53.23%(33/62),18例良性膀胱病变组织PTEN全部阳性表达;PTEN的表达与肿瘤分级密切相关(P<0.05)。结论PTEN基因突变或缺失所导致的表达障碍可能在膀胱癌的发生、发展中发挥重要的作用;PTEN表达的检测有助于肿瘤的诊断和判断其预后。
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| 关 键 词： | 膀胱癌 免疫组化 |
| 收稿时间： | 2004-08-20 |
| 修稿时间： | 2005-04-10 |
Expression and Significance of PTEN in Bladder TransitionalCell Carcinoma |
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| Jianhua ZHANG,Weimin YANG,Siwei ZHOU. Expression and Significance of PTEN in Bladder TransitionalCell Carcinoma[J]. The Chinese-German Journal of Clinical Oncology, 2005, 4(4): 218-220. DOI: 10.1007/s10330-004-0282-4 |
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| Authors: | Jianhua ZHANG Weimin YANG Siwei ZHOU |
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| Affiliation: | (1) Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China |
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| Abstract: | Objective: To explore the expression of anti-oncogene PTEN in bladder transitional cell carci- noma and its clinical significance. Methods: Using immunohistochemical S-P methods, the expression of PTEN gene was detected in 62 specimens of bladder cancer and 18 specimens of normal bladder tissue. Results: In the 62 bladder cancers, the positive rate of PTEN was 53.2% (33/62). All 18 normal blad- der tissues were positive for the PTEN expression. The expression of PTEN was negatively correlated to tumor grades (P<0.05). Conclusion: The reduced expression of PETN might play an important role in carcinogenesis and progression of bladder cancer. Detection of PTEN might be useful for judgement of tumor development and prognosis. |
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| Keywords: | PTEN transitional cell carcinoma PTEN gene immunohistochemistry |
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