The actions of cimetidine hydrochloride and mepyramine maleate in rat adjuvant arthritis |
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Authors: | Hussain A Al-Haboubi Isaac J Zeitlin |
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Institution: | Department of Physiology and Pharmacology, University of Strathclyde, 204 George Street, Glasgow G1 1XW, Scotland, U.K. |
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Abstract: | Adjuvant arthritis in rats was induced by a single subcutaneous injection of Freund adjuvant into a hind paw. The injected paws' mean volume increased continuously by 80±26% after 6 h (acute local response). The injected paw displayed a biphasic response peaking at day 1–2 decreasing to day 5, then increased to day 14 by 123% while the contralateral non-injected paw showed little increase until day 10 and increased by 42% at day 14. The lateral diameter of both knee-joints also increased biphasically, peaking at day 4, decreasing to day 6, then increasing to day 14 (early and late systemic phase). Mepyramine maleate, 1 mg·kg?1 (i.p.) daily, suppressed only the early systemic phase by 50%. Daily cimetidine hydrochloride, 1 mg·kg?1·day?1, almost completely abolished the inflammatory response in the knee joints up to day 12, while at day 14 the supression was 71%. The increase in mean paw volume was also suppressed by orally administered cimetidine. Intraperitoneal doses of cimetidine (3.5 μmol·kg?1) totally suppressed paw oedema produced by subplantar injection of histamine (1.8 mM) but had no action on equiactive dose of the specific H1-agonist, 2-pyridylethylamine. Mepyramine at 3.5 μmol·kg?1 or greater produced no more than 50% suppression of the histamine response. A component of both adjuvant and histamine-induced responses thus appears to be histamine H2-receptor mediated. |
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Keywords: | Arthritis (adjuvant) Inflammation Cimetidine Mepyramine Oedema |
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