生长抑素与垂体后叶素分别联合泮托拉唑治疗肝硬化静脉曲张破裂出血的随机对照试验

目的研究生长抑素与垂体后叶素分别联合泮托拉唑治疗肝硬化静脉曲张破裂出血的疗效和副作用。方法患者被随机分为治疗组和对照组,均给予静滴国产泮托拉唑40mg,一日二次。治疗组静脉注射国产生长抑素0.25mg,然后持续泵入0.25mg/h;对照组持续泵入垂体后叶素0.2-0.4u/min。结果治疗组和对照组48h止血有效率分别为90.32%、68.75%,二者相比有统计学差异（P〈0.05）。治疗组和对照组平均止血时间分别为（29±16.36）h、（38±17.58）h,治疗组所用止血时间少于对照组（P〈0.05）。治疗组不良反应少于对照组。结论生长抑素治疗肝硬化静脉曲张破裂出血较垂体后叶素更有效、更安全,不良反应更少;泮托拉唑有优良的抑酸作用,且价格相对低廉,临床工作中可进一步推广生长抑素联合泮托拉唑治疗肝硬化静脉曲张破裂出血。

Effects of somatostatin and pituitrin each combined with pantoprazole on variceal bleeding of liver cirrhosis:A randomized controlled trial

Objective To explore the curative effects and side reactions of somatostatin and pituitrin each combined with pantoprazole on variceal bleeding of liver cirrhosis. Methods Patients were assigned randomly to the therapeutic group and the control group, and all were given pantoprazole 40 mg intravenous transfusion, two times one day. For the therapeutic group, 0.25 mg somatostatin was given intravenous transfusion firstly, then 0. 25 mg/h. For the control group, pituitrin was given in 0.2 - 0.4^u/min. Other therapeutic measures were similar. Restilt.s The rate of stop bleeding in 48 h was 90.32% in the therapeutic group and 68.75% in the controlled group, and there was significantly difference between two groups （ P 〈 0.05）. Average stop bleeding time was 29. 00 ± 16. 36 h in the therapeutic group and 38.00 ± 17.58 h in the control group, and there was significantly difference between two groups （ P 〈 0.05 ）. The adverse effects in the therapeutic group were fewer than those in the control group. Conclusion Combined with pantoprazole, somatostatin was more effective and safe than pituitrin and had fewer adverse effects in the treatment of variceal bleeding of liver cirrhosis, and hence somatostatin combined with pantoprazole is worthy to be extended.