点阵激光改善皮肤光老化作用机制的研究进展

点阵激光已广泛用于治疗各种皮肤疾病，包括皮肤光老化、痤疮瘢痕和色素性疾病等，其利用点阵光热分解的原理，点阵激光作用皮肤后形成微治疗区，周围仍见正常组织，角质形成细胞快速从周围迁移、增殖和上皮化，从而促进快速愈合，停工期短。主要概述点阵激光改善皮肤光老化的研究进展，从组织学改变和分子水平作用机制进行阐述。

Mechanisms underlying the therapeu tic effect of fractional laser on photoaging

Fractional laser has been widely accepted as a treatment modality for a variety of skin conditions including photoaging, acne scars and pigmentary diseases. Based on the theory of local photothermolysis, fractional laser creates multiple microthermal zones （MTZs） surrounded by normal skin, followed by fast migration, proliferation and epithelialization of keratinocytes, which allows the timely wound healing with minimal downtime. This article presents an overview of recent advances in the treatment of skin photoaging with fractional laser, with an emphasis on histological changes and molecular mechanisms underlying fractional resurfacing.