| Cortactin与非小细胞肺癌侵袭和转移研究进展 |
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| 引用本文： | 王玲婵,陈刚,王东昌. Cortactin与非小细胞肺癌侵袭和转移研究进展[J]. 国际呼吸杂志, 2014, 34(18): 1398-1400 |
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| 作者姓名： | 王玲婵 陈刚 王东昌 |
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| 作者单位： | 河北医科大学第三医院呼吸内科,石家庄,050051 |
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| 基金项目： | 河北省省级重大医学科研课题 |
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| 摘 要： | 皮层肌动蛋白（Cortactin）是一种细胞骨架蛋白,通过细胞运动、细胞外基质降解、失巢凋亡及肿瘤细胞与细胞微环境基质之间黏附等多种途径参与肿瘤侵袭和转移.最近研究表明,Cortactin在非小细胞肺癌、结直肠癌、食管癌、肝癌、乳腺癌、骨肉瘤等肿瘤组织中过度表达,与多种肿瘤的侵袭和转移密切相关.本文就Cortactin的结构、在肿瘤侵袭和转移中的作用及与非小细胞肺癌的关系作一综述.
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| 关 键 词： | 皮层肌动蛋白 非小细胞肺癌 侵袭 转移 |
Cortactin in non-small cell lung cancer invasion and metastasis |
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| Wang Lingchan,Chen Gang,Wang Dongchang. Cortactin in non-small cell lung cancer invasion and metastasis[J]. International Journal of Respiration, 2014, 34(18): 1398-1400 |
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| Authors: | Wang Lingchan Chen Gang Wang Dongchang |
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| Affiliation: | (Department of Respiratory Medicine, the Third Affiliated Hospital, Hebei Medical University, Shijiazhuang 050051 , China) |
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| Abstract: | Cortactin is a kind of cytoskeletal protein.It involves in tumor invasion and metastasis by cell motility,extracelhlar matrix degradation,anoikis,cell adhesion between tumor ceils and stromal microenvironment and other pathways.Recent studies have shown that Cortactin is overexpressed in many malignant tumors,including non small cell lung cancer,colorectal carcinoma,esophageal squamous cell carcinoma,hepatocellular tumor,breast cancer,and osteosarcoma.This review summarizes the structure,role in tumor invasion and metastasis,and relationship with non-small cell lung cancer of Cortactin. |
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| Keywords: | Cortactin Non-small cell lung cancer Invasion Metastasis |
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