| 硫辛酸胶囊干法制粒工艺研究 |
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| 引用本文： | 马宏达,张晋,郭桐宇,史英,史国兵.硫辛酸胶囊干法制粒工艺研究[J].解放军药学学报,2014(2):156-158. |
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| 作者姓名： | 马宏达 张晋 郭桐宇 史英 史国兵 |
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| 作者单位： | 沈阳军区总医院药剂科,辽宁沈阳110016 |
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| 摘 要： | 目的研究硫辛酸胶囊干法制粒的最佳工艺条件。方法考察轧辊压力、轧辊转速和物料传送速度对颗粒得率（20目～60目）的影响，采用L。（3。）正交试验优化于法制粒工艺参数。结果最佳工艺参数为轧辊压力3MPa，轧辊转速4r·min^-1，物料传送速度18r·min^-1。结论硫辛酸胶囊干法制粒工艺的研究为硫辛酸胶囊研究与生产提供技术参考。
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| 关 键 词： | 硫辛酸胶囊 干法制粒 正交试验 |
Dry Granulation Technique for Alpha Lipoic Acid Capsules |
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| MA Hong-da,ZHANG Jin,GUO Tong-yu,SHI Ying,SHI Guo-bing.Dry Granulation Technique for Alpha Lipoic Acid Capsules[J].Pharmaceutical Journal of Chinese People's Liberation Army,2014(2):156-158. |
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| Authors: | MA Hong-da ZHANG Jin GUO Tong-yu SHI Ying SHI Guo-bing |
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| Institution: | ( General Hospital of Shenyang Military Command,Shenyang 110016,China) |
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| Abstract: | Objective To optimize the dry granulation technology of alpha lipoic acid capsules. Methods L9 （34） orthogonal text was used to optimize dry granulation technology with wheel speed, wheel rolling pressure and feeding speed as parameters. Results The optimal dry granulation technology was as follow：rolling pressure at 3 MPa, rolling speed at 4 r·min^-1 and powder feeding rate at 18 r ·min^-1. Conclusion This study on the roller compaction technique of alpha lipoic acid capsules provides some technical reference for future research and pro-duction. |
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| Keywords: | alpha lipoic acid capsules dry granulation orthogonal design |
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