弹性纤维与皮肤衰老

成熟的弹性纤维主要由弹性蛋白、原纤维蛋白微纤维及与弹性纤维有关的蛋白组成。内源性老化的皮肤弹性和柔韧度降低，弹性纤维网断裂和衰退。光老化皮肤不仅是富含原纤维蛋白的微纤维在表皮真皮交界处丢失，弹性蛋白变性，更重要的是在真皮深层混乱的弹性纤维蛋白物质的沉积，弹性蛋白的功能也受到影响。弹性纤维的修复可归纳为促进组成蛋白表达、改善组装条件、减少破坏因素3方面。

Elastic fibers and skin aging

Mature elastic fibers are mainly composed of elastin, fibrillin microfibrils and some proteins. Endogenously aged skin is manifested as a decrease in skin elasticity and flexibility as well as rupture and degeneration of elastic fibers, while photoaged skin not only involves disappearance of fibrillin-rieh microfibrils in the epidermal-dermal junction, denaturation of elastic protein, but also deposition of disarranged elastic fibrous protein materials in the deep dermis with impaired function of elastic protein. The repair of elastic fibers may be realized by promoting component protein expression, improving assembly condition and redueing damage-related factors.