大鼠中央杏仁核中神经降压肽样和甘丙肽样神经元的老年变化

用免疫组织化学及显微分光光度计研究了大鼠中央杏仁核中神经降压肽样(NT-L)及甘丙肽样(GAL-L)胞体及纤维终末的老年变化。NT-L胞体主要位于中央外侧杏仁核中央部(CeLn)。中央外侧杏仁核囊部(CeLc)及中央内侧杏仁核(CeM)亦有少量分布。NT-L纤维终末主要位于CLen及CeLc。GAL-L胞体仅位于中央内侧杏仁核。老年大鼠中央杏仁核的NT-L胞体数量及纤维终末密度显著减少。GAL-L胞体的数量无明显年龄变化,但胞体中染色的深度明显降低。本文结果表明,大鼠中央杏仁核中NT-L及GAL-L神经元有明显的老年变化,这种变化的意义有待进一步研究。

AGING CHANGES OF NEUROTENSIN-LIKE AND GALANIN-LIKE NEURONS IN THE CENTRAL AMYGDALOID NUCLEUS OF THE RAT

Aging changes of neurotensin-like (NT-L) and galanin-like (GAL-L) cell bodies and fiber terminals in the central amygdaloid nucleus between the young and old rats were studied by means of immunohistochemical and microspectrophotometric techniques. NT-L cell bodies were mainly located in the central part (CeLn) of, centrolateral amygdaloid nucleus, a few of NT-L neurons were also found in the centrolateral amygdaloid nucleus, capsular part (CeLc) and centromedial amygdaloid nucleus (CeM). NT-L fiber terminals were seen mainly in the CeLn and CeLc. GAL-L cell bodies were observed only in the CeM. A marked decrease of density of NT-L cell bodies and fiber terminals in the central amygdaloid nucleus was found in the old rats as compared with young animals. No significant age difference in number of GAL-L cell bodies was observed in the central amygdaloid nucleus, but the staining intensity of GAL-L cell bodies was reduced remarkably. The results show that there are apparent changes with aging of the NT-L and GAL-L neurons in the central amygdaloid nucleus of the rat. The significance of the changes remains to be studied further.