冠状动脉慢血流现象的研究进展

冠状动脉慢血流现象的病因及病理机制尚不明确,近年来的研究认为,吸烟、高同型半胱氨酸等与冠状动脉慢血流现象的发生密切相关,内皮功能损伤和炎性反应可能参与病理生理机制并发挥重要作用。冠状动脉慢血流现象可引起心肌缺血,临床上可表现为心绞痛或急性冠状动脉综合征,甚至猝死。小样本随访研究也表明,冠状动脉慢血流现象预后较差。现就冠状动脉慢血流现象的病因、病理生理机制、临床特点、诊治和预后综述如下。

Advances in Coronary Slow Flow Phenomenon

The etiology and pathogenesis of the coronary slow flow phenomenon（CSFP） is still unclear.Recent studies indicate that smoking and high levels of blood homocysteine are closely related to the onset of CSFP.Endothelial dysfunction and the inflammatory reaction may also be involved in the progression of the pathophysiology.CSFP can cause myocardial ischemia,which may lead to angina pectoris or acute coronary syndrome,or even sudden death.Follow-up studies using small sample sizes suggest that the prognosis is much worse.This article summarizes the etiology,pathogenesis,clinical features,diagnosis,treatment,and prognosis of the coronary slow flow phenomenon.