| 瑶宝克癌灵胶囊抗肿瘤作用机制研究 |
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| 引用本文： | 赵成国,;秦书芝,;毛晶磊,;吴丽艳,;肖洪彬. 瑶宝克癌灵胶囊抗肿瘤作用机制研究[J]. 西部中医药, 2014, 0(5): 7-9 |
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| 作者姓名： | 赵成国, 秦书芝, 毛晶磊, 吴丽艳, 肖洪彬 |
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| 作者单位： | [1]吉林大学珠海学院,广东珠海519041; [2]大庆油田总医院;,广东珠海519041; [3]黑龙江中医药大学,广东珠海519041; |
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| 摘 要： | 目的：从分子生物学角度探讨瑶宝克癌灵胶囊抗肿瘤的作用机理。方法：采用双抗体夹心ELISA法检测S180荷瘤小鼠外周血白细胞介素-2（IL-2）、γ-干扰素（IFN-γ）的含量；采用免疫组化法检测凋亡相关基因突变型p53和Bcl-2基因的表达。结果：瑶宝克癌灵胶囊可明显增加小鼠外周血IL-2、IFN-γ的含量，可抑制突变型基因p53和Bcl-2基因的表达。结论：瑶宝克癌灵胶囊抗肿瘤的作用机制可能与增强荷瘤小鼠免疫功能，抑制突变型基因p53和Bcl-2基因的表达有关。
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| 关 键 词： | 瑶宝克癌灵胶囊 IL-2 IF-γ p5 3 Bcl-2 |
Investigation on Anti-tumor Mechanism of YaoBao KeA iLing Capsules |
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| Affiliation: | ZHAO Chengguo, QIN Shuzhi, MAO Jinglei, WU Liyan, XIAO Hongbin(1 Zhuhai College of Jilin University, Zhuhai 519041, China,2 Daqing Oilfield General Hospital; 3 Heilongjiang University of Chinese Medicine) |
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| Abstract: | Objective： To explore anti-tumor mechanism of YaoBoo KeA iLing capsules with molecular biology. Methods： The contents ofinterleukin-2 （IL-2） and interferon-γ（IFN-γ） were detected with double antibody sand- wich ELISA method; the expressions of Bcl-2 gene and p53 were measured by immunohistochemical method. Results： YaoBoo KeA iLing capsules could increase the contents of IL-2 and IFN-γ in peripheral blood of mice, inhibit the expressions of p53 and Bcl-2. Conclusion： Anti-tumor mechanism of YaoBao KeA iLing capsules might be relat- ed to increasing the immunity of the mice, inhibiting the expressions of p53 and Bcl-2. |
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| Keywords: | YaoBao KeAiLiug capsules IL-2 IFN-γ p53 Bcl-2 |
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