麻黄附子细辛汤治疗急性呼吸窘迫综合征临床观察

目的：观察麻黄附子细辛汤治疗急性呼吸窘迫综合征（ARDS）的疗效。方法：将ICU收治的ARDS患者126例按随机数字表法分为治疗组和对照组各63例，2组患者均予控制原发病的治疗，治疗组在此基础上予麻黄附子细辛汤每日1～2剂口服或鼻饲。治疗3周对2组患者基本情况评分及应用抗生素时间，抗生素使用率，抗生素使用强度（DDDS）以及血管活性药物、肾上腺皮质激素应用时间，机械通气时间，ICU住院时间，死亡率等进行比较。结果：治疗后Marshall评分治疗组为（5.23＆#177;2.25）分，与对照组（6.10＆#177;1.42）分比较P＜0.05；APACHEⅡ评分治疗组为（10.36＆#177;4.78）分，与对照组（14.31＆#177;2.13）分比较P＜0.05；PaO2/FiO2治疗组为（342.00＆#177;56.34）mmHg，与对照组（296.00＆#177;42.63）mmHg比较（P＜0.05）；2组应用抗生素时间、抗生素使用率、DDDS、血管活性药物应用时间，机械通气时间、死亡率、ICU住院时间等比较差异具有统计学意义（P＜0.05）。结论：在治疗原发病基础上采用麻黄附子细辛汤治疗ARDS安全有效。

Curative Observation on MaHuang FuZi XiXin Decoction in Treating Acute Respiratory Distress Syndrome

Objective： To investigate therapeutic effects ofMaHuangFuZiXiXindecoction in treating acute respiratory distress syndrome （ARDS）. Methods： All 126 patients admitted to ICU were allocated to the treatment group and the control group by random number table method, on the foundation of the treatment for primary disease, the treatment group receivedMaHuangFuZiXiXindecoction by mouth or nasal feeding. The scores of basic condi-tions of the patients in both groups, the time and the rate of using antibiotics, DDDS, the time of vasoactive agent, the time of adrenal cortex hormone, mechanical ventilation time, ICU hospitalization time, death rate and others were compared after treating for three weeks. Results： After treating, Marshall scores of the treatment group were （5.23＆#177;2.25）, which were compared to （6.10＆#177;1.42） of the control groupP＆lt;0.05; APACHEⅡscores of the treatment group were （10.36＆#177;4.78）, they were compared with （14.31＆#177;2.13） of the control groupP＆lt;0.05; PaO2/FiO2 of the treatment group were （342.00＆#177;56.34） mmHg, higher than（296.00＆#177;42.63）mmHg of the control groupP＆lt;0.05; the difference showed statistical meaning in the time and the rate of using antibiotics, DDDS, the time of vasoactive a-gent, mechanical ventilation time, death rate, ICU hospitalization time and others （P＆lt;0.05）. Conclusion：MaHuang FuZiXiXindecoction is safe and effective in treating ARDS.