夫妻活体供肾移植与血缘亲属供肾移植

背景：夫妻间活体肾移植尽管在组织配型方面差于血缘关系供肾移植，但在临床实践观察中夫妻肾移植与血缘关系肾移植间近期疗效并无明显差异。目的：对比同期实施的夫妻活体供肾移植和血缘亲属供肾移植的临床疗效，总结夫妻活体供肾移植的临床经验。方法：回顾性分析郑州人民医院实施的夫妻活体供肾移植18例及血缘亲属供肾移植100例的临床资料，通过对两组移植前组织配型情况和移植后(1，3，6个月)肾功能恢复情况，移植肾功能延迟恢及半年内急性排斥反应发生率、感染发生率等指标的分析，对夫妻活体供肾移植和血缘亲属供肾移植的临床疗效进行比较。结果与结论：同期进行的18例夫妻活体供肾移植组织配型情况较血缘关属供肾移植患者情况差。在移植方案及免疫抑制治疗方案相同的情况下，夫妻活体供肾移植后6个月内血肌酐恢复情况、术后移植肾功能延迟恢、急性排斥反应发生率、感染发生率，均与同期进行的血缘亲属活体供肾移植差异无显著性意义(P > 0.05)。结果表明，无血缘关系的夫妻间供肾移植与血缘亲属供肾移植治疗效果相近。

Living unrelated donor kidney transplantation between spouses and living related donor kidney transplantation

BACKGROUND: Living unrelated donor kidney transplantation between spouses is poorer than living related donor kidney transplantation in tissue matching, but clinical practice shows that there is no obvious difference in short-term curative effects between these two types of kidney transplantation. OBJECTIVE: To compare the clinical curative effects between living unrelated donor kidney transplantation between spouses and living related donor kidney transplantation and summarize the clinical experience of kidney transplantation between spouses. METHODS: A retrospective clinical data analysis was made regarding 18 patients who received kidney transplantation between spouses and 100 patients who received living related donor kidney transplantation. The clinical curative effects were compared between these two types of kidney transplantation by analyzing some indices including tissue matching before transplantation and renal function recovery, acute rejection and infection incidence at 1, 3, and 6 months. RESULTS AND CONCLUSION: Tissue matching before transplantation was poorer in 18 patients undergoing kidney transplantation between spouses than in 100 patients undergoing living related donor kidney transplantation. Under the same transplantation proposal and immunosuppressive therapy, there was no significant difference in serum creatinine level, renal function recovery, acute rejection, and infection incidence within 6 months after transplantation between kidney transplantation between spouses and living related donor kidney transplantation (P > 0.05). These findings suggest that the clinical curative effects are similar between living unrelated donor kidney transplantation between spouses and living related donor kidney transplantation.