| 透析法制备生物素化高分子纳米粒子及粒径控制 |
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| 引用本文： | 李资玲,龚妍春,李玉萍,熊向源.透析法制备生物素化高分子纳米粒子及粒径控制[J].中国神经再生研究,2011,15(34):6379-6381. |
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| 作者姓名： | 李资玲 龚妍春 李玉萍 熊向源 |
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| 作者单位： | 江西科技师范学院生命科学学院,江西科技师范学院生命科学学院,江西科技师范学院生命科学学院,江西科技师范学院生命科学学院 |
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| 基金项目： | 国家自然科学基金项目(50763003) |
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| 摘 要： | 背景：国内关于透析法控制粒径大小方面的研究报道较少。
目的：考察制备方式及制备条件等对生物素化高分子纳米粒子粒径大小的影响。
方法：采用透析法制备生物素化两亲性共聚物纳米粒子，通过单因素实验对比纳米粒子粒径的大小。
结果与结论：采用有机相滴加至水相的制备方法获得的粒径大小较适合用于药物载体，且初始有机溶剂加入量对粒径的影响较大。
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| 关 键 词： | 生物素 两亲性共聚物 透析法 纳米粒子 粒径 |
| 收稿时间： | 3/7/2011 12:00:00 AM |
| 修稿时间： | 3/7/2011 12:00:00 AM |
Preparation and size control of biotinylated polymeric nanoparticles by dialysis method |
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| Institution: | College of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi Province, China,College of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi Province, China,College of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi Province, China and College of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi Province, China |
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| Abstract: | BACKGROUND: Few reports about the particle size control by dialysis method have been published in China.
OBJECTIVE: To investigate the effect of preparation method and condition on particle size.
METHODS: Biotinylated polymeric nanoparcticles were prepared by a dialysis method. The particle size was compared by one-factor experimental design.
RESULTS AND CONCLUSION: The size of polymeric nanoparticles obtained from the addition of organic phase into water is pretty suitable for their application in drug delivery carriers. In addition, the amount of initial organic solvent plays an important role in the particle size. |
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| Keywords: | Biotin amphiphilic block copolymer dialysis method nanoparticles |
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