| 羟乙基淀粉130/0.4改善大鼠心肌缺血再灌注损伤 |
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| 引用本文： | 孙海静,刘波,邹最,王亚华,朱秋峰,袁红斌,石学银.羟乙基淀粉130/0.4改善大鼠心肌缺血再灌注损伤[J].第二军医大学学报,2009,30(8):947-949. |
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| 作者姓名： | 孙海静 刘波 邹最 王亚华 朱秋峰 袁红斌 石学银 |
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| 作者单位： | 1. 第二军医大学长征医院麻醉科,上海,200003
2. 沈阳军区总医院麻醉科,沈阳,110016 |
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| 基金项目： | 军队“十一五”科技攻关项目(08G071). |
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| 摘 要： | 目的:观察羟乙基淀粉(HES)130/0.4(万汶)对缺血再灌注(I/R)损伤心肌的干预作用，探讨其可能的作用机制。方法:24只SD大鼠随机均分为4组(n=6)：假手术(S)组、缺血再灌注(IR)组、白蛋白-缺血再灌注(A-IR)组、HES-缺血再灌注(H-IR)组。后3组建立在体大鼠心肌I/R模型，分别在缺血25 min时股静脉持续泵入生理盐水、5%白蛋白或HES 130/0.4，假手术组行开胸手术但不结扎左冠状动脉前降支。再灌注180 min处死大鼠，取心肌组织观察病理学改变；处死前颈动脉采血ELISA法测定TNF-α、IL-1β浓度；测定心肌组织NF-κB活性。结果:H-IR组心肌组织损伤病理学改变较IR组、A-IR组减轻。IR组、A-IR组、H-IR组血清TNF-α、IL-1β水平和心肌NF-κB活性明显高于S组(P<0.05)，但其中H-IR组血清TNF-α、IL-1β水平及心肌NF-κB活性上升程度不及IR组、A-IR组(P<0.05)。结论:羟乙基淀粉130/0.4能减轻缺血再灌注所致心肌病理损伤，可能与其抑制NF-κB的活性、减少促炎细胞因子的释放有关。
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| 关 键 词： | 心肌再灌注损伤 肿瘤坏死因子α 白细胞介素1β NF-κB 羟乙基淀粉 |
| 收稿时间： | 2009/2/24 0:00:00 |
| 修稿时间： | 6/1/2009 12:00:00 AM |
Protective effects of hydroxyethyl starch 130/0.4 against myocardial ischemia-reperfusion injury in rats |
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| SUN Hai-jing,LIU Bo,ZOU Zui,WANG Ya-hu,ZHU Qiu-feng,YUAN Hong-bin,SHI Xue-yin.Protective effects of hydroxyethyl starch 130/0.4 against myocardial ischemia-reperfusion injury in rats[J].Academic Journal of Second Military Medical University,2009,30(8):947-949. |
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| Authors: | SUN Hai-jing LIU Bo ZOU Zui WANG Ya-hu ZHU Qiu-feng YUAN Hong-bin SHI Xue-yin |
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| Affiliation: | SUN Hai-jing1,LIU Bo2,ZOU Zui1,WANG Ya-hua1,ZHU Qiu-feng1,YUAN Hong-bin1,SHI Xue-yin11.Department of Anesthesio1ogy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China2.Department of Anesthesio1ogy,General Hospital,PLA Shenyang Military Area Comm,,Shenyang 110016 |
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| Abstract: | Objective:To explore the influence of hydroxyethyl starch(HES) 130/0.4 on myocardial ischemia-reperfusion(I/R) injury in rats and the possible mechanism.Methods:Twenty-four SD rats were evenly randomized into four groups(n=6):the sham operation group,the I/R(IR) group,albumin + I/R(A-IR) group,and HES+I/R(H-IR) group;rats in the latter three groups were made into I/R models and were treated respectively with 7.5 ml/kg saline,5% albumin and HES 130/0.4 through femoral vein at 25 min of ischemia.At 180 min of... |
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