Formation, properties and antimicrobial activities of cotton xanthate-Cu(II)-homosulfamine complex |
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Authors: | Neung Jin Ha Yun Jin Jung Jeoung Soo Lee Youn Taeg Kim Young Mi Kim |
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Affiliation: | (1) Hanmi Pharmaceutical Co., Hwasung, 609-735 Kyungkido, Korea;(2) The Research Institute of Drug Development, College of Pharmacy, Pusan National University, 609-735 Pusan, Korea |
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Abstract: | To develop a cotton derivatives with prolonged antimicrobial activities, homosulfamine (Hs) was coupled to cotton xanthate (CX) via chelate bond in the presence of Cu(II) ion by one-and two-bath processes. In one-bath process, CX was treated with Cu(II)-Hs solution. In two-bath process, CX was treated with Cu(II) ion solution to produce CX-Cu(II) complex, which was isolated and treated in turn with Hs solution. Effects of concentration, Cu(II)/Hs ratio, and pH on the binding of Hs were investigated at 10°C. In one-bath process, binding of Hs took place readily with optimum pH around 5∼6. The amount of binding increased to give a maximum within 5 min and decreased slowly to establish an equilibrium within an hour. In two-bath process, binding of Hs was much lower than that of one-bath process. Release of Hs from CX-Cu(II)-Hs was investigated by batch and flow method. Antimicrobial activities of CX-Cu(II)-Hs were tested againstStaphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa andEscherichia coli and it showed prolonged activity compared to that of free Hs. |
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Keywords: | Cotton xanthate-Cu(II)-homosulfamine complex Cotton derivatives Antimicrobial activity |
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