| 干扰素与拉米夫定治疗慢性乙型肝炎的成本-效果分析 |
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| 引用本文： | 陈安进,张芳,徐艳. 干扰素与拉米夫定治疗慢性乙型肝炎的成本-效果分析[J]. 中国药房, 2007, 18(26): 2010-2011 |
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| 作者姓名： | 陈安进 张芳 徐艳 |
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| 作者单位： | 青岛市市立医院,青岛市,266011 |
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| 摘 要： | 目的:评价干扰素与拉米夫定治疗慢性乙型肝炎的经济学效果。方法:对2种治疗方案进行成本-效果分析,并运用Bootstrap法进行敏感度分析。结果:干扰素组、拉米夫定组的成本-效果比分别为9 128.31、11 491.70;以成本较低的干扰素组为基本组,拉米夫定组的增量成本-效果比为45 727.01;Bootstrap分析得拉米夫定组的增量成本平均中值为46 236.24。结论:干扰素治疗方案虽有效率较低,但从药物经济学角度分析,为治疗慢性乙型肝炎的较佳方案。
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| 关 键 词： | 干扰素 拉米夫定 慢性乙型肝炎 成本-效果分析 Bootstrap分析 |
| 文章编号： | 1001-0408（2007）26-2010-02 |
| 收稿时间： | 2007-01-22 |
| 修稿时间： | 2007-05-21 |
Interferon vs.Lamivudine for Chronic Type B Hepatitis: Analysis of Cost- Effectiveness |
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| CHEN Anjin,ZHANG Fang,XU Yan. Interferon vs.Lamivudine for Chronic Type B Hepatitis: Analysis of Cost- Effectiveness[J]. China Pharmacy, 2007, 18(26): 2010-2011 |
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| Authors: | CHEN Anjin ZHANG Fang XU Yan |
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| Affiliation: | Qingdao Municipal Hospital, Qingdao 266011, China |
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| Abstract: | OBJECTIVE: To evaluate the pharmacoeconomic effectiveness of interferon vs.lamivudine for chronic Type B hepatitis.METHODS: The cost-effectiveness analysis was carried out to evaluate two therapeutic schemes for chronic Type B hepatitis,and Bootstrap analysis was performed for sensitivity analysis.RESULTS: The cost-effectiveness ratios of interferon and lamivudine were 9 128.31 and 11 491.70,respectively.As compared with low cost interferon group,the incremental cost-effectiveness ratio in lamivudine group was 45 727.01.The median of incremental cost in lamivudine group obtained from Bootstrap analysis was 46 236.24.CONCLUSION: Pharmacoeconomically,interferon scheme is optimal for chronic Type B hepatitis in spite of its lower effectiveness rate as compared with lamivudine scheme. |
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| Keywords: | Interferon Lamivudine Chronic type B hepatitis Cost-effectiveness analysis Bootstrap analysis |
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