冠状动脉内支架置入选择及对不良事件发生的预测

药物涂层支架主要由支架、基质和药物3部分组成。药物涂层支架以金属支架为载体携带药物到达血管损伤局部，使药物在较长的时间内充分释放到血管壁内，减少支架置入后再狭窄的发生。抗炎药物涂层支架主要药物为地塞米松、甲泼尼龙等。抗迁移、抗增生药物涂层支架主要药物为雷帕霉素、紫杉醇、放线菌素D等。支持内膜愈合的药物涂层支架主要药物为雌二醇等。经皮冠状动脉支架置入可诱导和加重局部炎症反应，这对血管内皮的增生与再狭窄有重要影响，部分反映急性炎症反应的敏感指标如血清C-反应蛋白的浓度、血清脂蛋白、血清白细胞介素10、血清白细胞介素18等对于经皮冠状动脉支架置入后心血管事件的发生有预测价值。

Selection of coronary stents and prediction of cardiovascular events

Drug-eluting stent is composed of sent, matrix and drug. With metal stent as the carrier, drug is transferred to the damage vessels, slowly released into the vascular wall and inhibiting in-stent restenosis. Anti-inflammatory drug-eluting stent mainly includes dexamethasone and methylprednisolone. Anti-migratory and anti-proliferative drug-eluting stent includes rapamycin, paclitaxel and actinomycin D. Drug-eluting stent supporting intima healing mainly involves estradiol. Coronary artery stent implantation can induce and aggravate local inflammatory reaction, which has important influence on vascular endothelial hyperplasia and restenosis. Some sensitive indexes for acute inflammatory reaction, such as levels of C-reactive protein, lipoprotein, serum linterleukin-10 and interleukin-18, have predictive values for cardiovascular events following coronary artery stent implantation.