Randomized, double-blinded, placebo-controlled trial of ondansetron plus dexamethasone with or without metoclopramide as antiemetic prophylaxis in patients receiving high-dose cisplatin in medical practice |
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| Authors: | Suthinee Ithimakin Kanakorn Runglodvatana Akarin Nimmannit Charuwan Akewanlop Vichien Srimuninnimit Narong Keerativitayanan Nopadol Soparattanapaisarn Apirom Laocharoenkeat |
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| Affiliation: | (1) Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand;(2) Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand;(3) Pharmacy Department, Siriraj Hospital, Bangkok, Thailand |
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| Abstract: | Purposes Ondansetron plus dexamethasone are standard antiemetic agents for highly emetogenic chemotherapy. Metoclopramide is a dopamine antagonist, which may enhance efficacy of ondansetron and dexamethasone. The objective of this study was to assess the efficacy and tolerability of metoclopramide added to standard antiemetic regimen for prophylaxis of cisplatin-induced emesis. |
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