地乌胶囊长期毒性试验

目的：观察连续给予地乌胶囊后可能对机体产生的毒性反应，为临床安全用药提供试验依据。方法：地乌胶囊灌胃给药，3组大鼠一日用药剂量分别为4g/kg,2g/kg及1g/kg，相当于成人（50kg)，一日口服量（0.06g/kg)的66．67倍，33．33倍，16．67倍，试验期为70d，相当于临床用药的3个疗程。结果：试验期间大鼠饮食，活动及大小便等均正常，体重增长，血象，血液一化指标，脏器系数，脏器组织的肉眼和病理组织学检查结果均未见异常，与正常对照相比，均无显性差异（P＞0．05）,停药2周后，各项指标检查亦未见异常。结论：地乌胶囊在临床用药剂量范围内是安全的。

The Iong - Term Toxic Test of Diwu Capsule

To observe the possible toxic reaction to organism of Diwu capsule after Coutinuous affering Diwu Capsule to affer trial evidences for clinical use of medicine of safety. Methods: The method of perfusive stomach, three groups of large white rats fill Diwu capsule daily dosage of medicine: 4g/kg, 2g/kg and 1g/kg, as the amount of a mature people (50kg) daily dosage medicine 0.06g/kg, as 66.67 times, 33.33 times and 16.67 times, trial time is to days, as the clinical usage of medicine 3 pe-rionds of time. Results: During the tried time, the large white rats ate a lot, activity, excrement and urine keeps normal; weight gain, the reult of hemogram, blood chemical examination, organ coefficient, organ organization, macroscopic and histopathology examination keeps normal, compared to regartarity, it has nothing unusual (P > 0.05) after stopping medicine for two weeks, each examination also has nothing unusual. Conclusion: Diwu capsule is safe within the clinical dosage of medicine.