| Therapeutic effectiveness of interferon alpha on hepatitis B virus DNA in peripheral blood mononuclear cells |
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| 引用本文： | 郭亚兵,张继锁,侯金林,姜荣龙,顾晓维,骆抗先.Therapeutic effectiveness of interferon alpha on hepatitis B virus DNA in peripheral blood mononuclear cells[J].中国人民解放军军医大学学报,1996(3). |
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| 作者姓名： | 郭亚兵 张继锁 侯金林 姜荣龙 顾晓维 骆抗先 |
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| 作者单位： | Department of Infectious Diseases，Nanfang Hospital，First Military Medical University，Guangzhou，510515 |
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| 摘 要： | ＴｈｅｒａｐｅｕｔｉｃｅｆｆｅｃｔｉｖｅｎｅｓｓｏｆｉｎｔｅｒｆｅｒｏｎａｌｐｈａｏｎｈｅｐａｔｉｔｉｓＢｖｉｒｕｓＤＮＡｉｎｐｅｒｉｐｈｅｒａｌｂｌｏｏｄｍｏｎｏｎｕｃｌｅａｒｃｅｌｌｓＧｕｏＹａｂｉｎｇ（郭亚兵）；ＺｈａｎｇＪｉｓｕｏ（张继锁）；...
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Therapeutic effectiveness of interferon alpha on hepatitis B virus DNA in peripheral blood mononuclear cells |
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| Guo Yabing, Zhang Jisuo,Yang Yunfen,Zhang Lian,Hou Jinlin,Jiang Ronglong, Gu Xiaowei,Luo Kangxian.Therapeutic effectiveness of interferon alpha on hepatitis B virus DNA in peripheral blood mononuclear cells[J].Journal of Medical Colleges of PLA(China),1996(3). |
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| Authors: | Guo Yabing Zhang Jisuo Yang Yunfen Zhang Lian Hou Jinlin Jiang Ronglong Gu Xiaowei Luo Kangxian |
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| Abstract: | Six patients with chronic hepatitis B were investigated for hepatitis B virus (HBV) DNA both in serum and in peripheral blood mononuclear cells (PBMC) by polymerase chain reaction (PCR) before ,during and after interferon alpha (IFN-a)treatment.All patients responded to IFN therapy with remission of serum alanine aminotransferase (ALT).HBV DNA disappeared in serum of 6 and in PBMCs of 5 patients during the treatment with IFN-a. The average elimination period was 5 weeks (range 3-10 weeks) in serum and 15 weeks (range 12-20weeks) in PBMCs. Relapse of serum ALT was seen in one patient with HBV DNA in PBMCs persistently positive during and after treatment with IFN-a. The results showed that clearance of HBV DNA was more difficult in PBMCs than that in serum,and that the persistent appearance of HBV DNA in PBMCs during and after treatment with IFN-a may imply the failure of IFN therapy. |
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| Keywords: | interferon hepatitis B virus peripheral blood mononuclear cells polymerase chain reaction |
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