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Diagnostic and prognostic significance of t(1;3)(p36;q21) in the disorders of hematopoiesis
Authors:J L Welborn  J P Lewis  H Jenks  P Walling
Affiliation:1. Department of Internal Medicine; The University of California at Davis, Davis, CA USA.;2. Department of Pathology; The University of California at Davis, Davis, CA USA.;1. Department of Sociology, Mountain Agriculture Research Centre, University Innsbruck, Universitätsstrasse 15, 6020 Innsbruck, Austria;2. Institute of Agricultural and Forestry Economics, Department of Economic and Social Sciences, BOKU—Univ. of Natural Resources and Life Sciences, Feistmantelstr. 4, 1180 Vienna, Austria;3. Department of Geography, Norwegian University of Science and Technology, NTNU NO-7491 Trondheim, Norway;4. Laboratoire d''Ecologie Alpine, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France;1. Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;2. Leukemia Program, Translational Hematology and Oncology Research and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH;3. Department of Leukemia, MD Anderson Cancer Center, Houston, TX;4. Department of Malignant Hematology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD;5. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;6. Department of Malignant Hematology, Weill Cornell Medical College, New York, NY
Abstract:We describe a cytogenetic abnormality with important diagnostic and prognostic implications. The translocation t(1;3)(p36;q21) is an acquired chromosomal rearrangement associated with myelodysplastic syndromes, which have a high propensity for conversion to refractory acute nonlymphocytic leukemia.
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