| 温针灸对吗啡戒断大鼠NR2B受体表达影响的研究 |
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| 引用本文： | 卫哲,董哲,孙远征,尚颖. 温针灸对吗啡戒断大鼠NR2B受体表达影响的研究[J]. 针灸临床杂志, 2012, 28(5): 56-58 |
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| 作者姓名： | 卫哲 董哲 孙远征 尚颖 |
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| 作者单位： | 1. 黑龙江中医药大学附属第二医院,黑龙江哈尔滨,150001
2. 哈尔滨市儿童医院,黑龙江哈尔滨,150010 |
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| 基金项目： | 黑龙江省青年科学基金项目,编号:QC2011C040;黑龙江中医药大学校基金项目,编号:201013 |
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| 摘 要： | 目的:观察温针灸对吗啡戎断大鼠空间学习能力及脑区NR2B受体表达的影响.方法:采用逐日背部皮下注射盐酸吗啡注射液,末次注射后3h给予纳络酮快速戒断,建立吗啡戒断大鼠模型.给予温针灸治疗后,采用Morris水迷宫测试大鼠空间学习能力,免疫组化方法检测伏隔核脑区NR2B受体的表达.结果:温针灸组大鼠平台逃避潜伏期明显缩短(P＜0.01).温针灸组大鼠NAc脑区NMDA -NR2B受体表达增高(P＜0.05).结论:温针灸能提高大鼠的空间学习能力,其机制可能与调整脑区NR2B受体表达有关.
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| 关 键 词： | 温针灸 吗啡 戒断 Morris水迷宫 NR2B受体 |
Acupuncture with Warm Needle on the Expression of NR2B Receptor of Rats after Morphine Withdrawal |
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| WEI Zhe , DONG Zhe , SUN Yuan-zheng , SHANG Ying. Acupuncture with Warm Needle on the Expression of NR2B Receptor of Rats after Morphine Withdrawal[J]. Journal of Clinical Acupuncture and Moxibustion, 2012, 28(5): 56-58 |
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| Authors: | WEI Zhe DONG Zhe SUN Yuan-zheng SHANG Ying |
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| Affiliation: | 1 (1.The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China; 2.The Children’s Hospital of Harbin,Harbin 150010,China) |
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| Abstract: | Objective:To observe rats’ interpace learning ability and the expression of NR2B receptor in brain area by acupuncture with warm needle after morphine withdrawal.Methods:Establish a morphine dependent SD rat model.We adopted hypodermic injection by morphine in back day by day,and injected naloxone in order to rapid withdrawal after the last injection of three hours.We used Morris water maze to testing rats’ interpace learning ability.The expression of NR2B receptor in NAc brain areas of rats were measured by immunohistochemical method.Results:The escape latent period of flat roof in acupuncture with warm needle group rats was abbreviated obviously(P<0.01).The expression of NMDA-NR2B receptor heightened acupuncture with warm needle group(P<0.05).Conclusion:Acupuncture with warm needle can improve the ability of interpace learning.The mechanism is related to adjusting the expression of NR2B receptor probably. |
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| Keywords: | Warm needle acupuncture Morphine Withdrawal Morris water maze NR2B receptor |
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