Busseihydroquinones A-D from the roots of Pentas bussei |
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| Authors: | Endale Milkyas Ekberg Annabel Akala Hoseah M Alao John Patrick Sunnerhagen Per Yenesew Abiy Erdélyi Máté |
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| Affiliation: | Department of Chemistry, University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya. |
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| Abstract: | Four new naphthohydroquinones, named busseihydroquinones A-D (1-4), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH(2)Cl(2)/MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquine-resistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant. |
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