Hippocampal electrical correlates of free behavior and behavior induced by stimualtion of two hypothalamic- hippocampal systems in the cat. |
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| Authors: | J R Coleman D B Lindsley |
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| Institution: | 1. Department of Psychology, University of California, Los Angeles, California 90024 USA;2. Department of Physiology and Psychiatry, University of California, Los Angeles, California 90024 USA;3. Brain Research Institute, University of California, Los Angeles, California 90024 USA |
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| Abstract: | Bilateral dorsal and ventral hippocampal and anterior and posterior neocortical electrical activity was recorded in 11 cats during free behavior situations and during stimulation of medial and lateral hypothalamic systems which influence hippocampal electrical activity and behavior in distinct and contrasting ways. Behavioral states characterized by alertness, attentiveness, scanning, or investigatory activity were accompanied by hippocampal theta rhythm and by desynchronization of neocortical electrical activity. Behavioral states characterized by relaxed wakefulness, inattentiveness, or drowsiness were accompanied by high voltage irregular patterns of electrical activity in the hippocampus with no organized theta rhythms. Specific behaviors (alerting, orienting, scanning, or investigatory) emerging from relaxed behavioral states occurred concomitantly with hippocampal theta rhythm. Electrical stimulation of the medial hypothalamic system at 100 Hz elicited hippocampal theta rhythm and specific behaviors of alerting, orienting, scanning, and investigatory activity. In contrast, lateral hypothalamic stimulation at 100 Hz caused low voltage desynchronization of hippocampal electrical activity accompanied by postural stability and fixation of gaze. The relation of hippocampal theta rhythm to behavior is discussed in terms of brain stem-hypothalamic-hippocampal systems. |
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