| Box-Behnken Design-响应面优化法优化芍药总苷脂质体的制备工艺及体外释放研究 |
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| 引用本文： | 张丹,廖芳,周洁,邹林巧,李东芬.Box-Behnken Design-响应面优化法优化芍药总苷脂质体的制备工艺及体外释放研究[J].中草药,2015,46(3):359-364. |
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| 作者姓名： | 张丹 廖芳 周洁 邹林巧 李东芬 |
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| 作者单位： | 泸洲医学院药学院, 四川 泸洲 646000;成都市新都区中医医院, 四川 成都 610500;泸洲医学院药学院, 四川 泸洲 646000;泸洲医学院药学院, 四川 泸洲 646000;成都中医药大学, 四川 成都 611130 |
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| 基金项目： | 泸州科技局(2012-S-36);泸州医学院大学生科研项目(201387) |
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| 摘 要： | 目的研究芍药总苷(TGP)脂质体的最佳制备工艺及其体外释放情况。方法采用逆向蒸发法制备TGP脂质体,以包封率为评价指标,采用Box-Behnken Design-响应面优化法(BBD-RSM)优化最佳制备工艺参数,并对其体外释放情况进行考察。结果最佳处方为胆固醇与磷脂质量比为1∶2.7,TGP与脂类质量比为1∶29,水化介质用量5.1 m L,药物的平均包封率为73.0%,体外12 h累积释放率为42.18%。结论 TGP脂质体制备工艺合理可行,包封率高,稳定性好,有良好的缓释作用。
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| 关 键 词： | 芍药总苷 脂质体 Box-Behnken Design-响应面优化法 体外释放 缓释 |
| 收稿时间： | 6/4/2014 12:00:00 AM |
Optimization of preparation technology for total glucosides from Paeonia lactiflora liposome by BBD-RSM and its in vitro release |
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| ZHANG Dan,LIAO Fang,ZHOU Jie,ZOU Lin-qiao and LI Dong-fen.Optimization of preparation technology for total glucosides from Paeonia lactiflora liposome by BBD-RSM and its in vitro release[J].Chinese Traditional and Herbal Drugs,2015,46(3):359-364. |
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| Authors: | ZHANG Dan LIAO Fang ZHOU Jie ZOU Lin-qiao and LI Dong-fen |
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| Institution: | Department of Pharmacy, Luzhou Medical College, Luzhou 646000, China;The Traditional Chinese Medicine Hospital of Xindu District, Chengdu 610500, China;Department of Pharmacy, Luzhou Medical College, Luzhou 646000, China;Department of Pharmacy, Luzhou Medical College, Luzhou 646000, China;Chengdu University of Traditional Chinese Medicine, Chengdu 611130, China |
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| Abstract: | Objective To optimize the preparation technology for total glucosides from Paeonia lactiflora (TGP) liposome and study on its in vitro release. Methods Liposomes were prepared by reverse-phase evaporation technique. Taking the entrapment efficiency (EE) as indexes, the preparation of liposome was optimized using Box-Behnken design-response surface method (BBD-RSM), and the in vitro release was studied. Results The optimal formulation was cholesterol-lecithin (1:2.7), TGP-lipid (1:29), and hydrated medium of 5.1 mL. The average EE were 73.0% and the 12 h in vitro accumulative release rate was 42.18%. Conclusion The optimized process is rational and feasible, and the TGP liposome has the higher EE and good stability with better sustained release in vitro. |
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| Keywords: | total glucosides from Paeonia lactiflora liposome Box-Behnken design-response surface method in vitro release sustained release |
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