广州地区淋球菌对环丙沙星耐药的监测与分析

目的 为了解广州地区1998～2002年淋球菌对环丙沙星敏感性和耐药性的变迁。方法 采用琼脂稀释法测定环丙沙星对每年分离的淋球菌的最低抑菌浓度(MIC)。结果 对1998～2002年在广州市性病监测中心就诊的性病患者中分离到的603株淋球菌，进行耐药性分析，环丙沙星的敏感率由1998年的12％降至2002年的零敏感，而耐药率由1998年的56．5％上升至2002年的98％。结论 广州地区流行的淋球菌的耐药情况日趋严重，喹诺酮类药物的高耐药率表明已不再适宜被推荐为治疗淋病的一线药物。有必要持续监测淋球菌的耐药性，并减少抗菌药物的滥用，以保证药物的敏感性。

Investigation on the susceptibility and resistance of Neisseria gonorrhoeae to ciprofloxacin in Guangzhou from 1998 to 2002

Objective To survey susceptibility and resistance of Neisseria gonorrhoeae to ciprofloxacin in Guangzhou from 1998 to 2002.Method Minimum inhibitory concentrations(MIC)of ciprofloxacin to Neisseria gonorrhoeae isolated in individual years were determined by agar dilution method.Result The rate of susceptibility to ciprofloxacin decreased from 12% in 1998 to zero in 2002,and the rate of resistance increased from 56.5% in 1998 to 98% in 2002.Conclusion The resistant strains of contemporary gonococci in Guangzhou pose a very serious problem,and the high rate of resistance to ciprofloxacin suggests that this group of antibiotic cannot be used in the treatment of gonorrhea.In addition,it is needed to survey the resistance of Neisseriae gonorrhoeae to antibiotics in a continuous way.