| 肉苁蓉总苷对家兔失血性休克/再灌注损伤的治疗效应 |
| |
| 引用本文： | 梁明华,孙沛毅,杨晓梅,周杰.肉苁蓉总苷对家兔失血性休克/再灌注损伤的治疗效应[J].实用临床医药杂志,2002,6(6):516-517. |
| |
| 作者姓名： | 梁明华 孙沛毅 杨晓梅 周杰 |
| |
| 作者单位： | 江苏省扬州大学医学院,江苏扬州,225001 |
| |
| 摘 要： | 目的 :研究肉苁蓉总苷 (glycosidesofcistanche ,GC)对家兔失血性休克 /再灌注 (hemorrhagicshock/reperfusion ,S/R)损伤的治疗作用。方法 :应用家兔S/R模型 ,观察血浆中过氧化脂质 (LPO)含量、丙二醛 (MDA)含量、超氧化物歧化酶(SOD)活性和血栓素A2 (TXA2 )、前列环素 (PGI2 )代谢产物的浓度以及GC对上述指标的影响。结果 :与假手术组比较 ,S/R组LPO、MDA、TXB2 明显升高 ,SOD、6-酮 -PGF1α明显降低 ,GC可逆转上述指标的变化。结论 :GC对S/R损伤有治疗作用。
|
| 关 键 词： | 肉苁蓉总苷 休克 缺血再灌注损伤 家兔 |
| 文章编号： | 1007-6514(2002)06-0516-02 |
| 修稿时间： | 2001年5月16日 |
THE THERAPEUTIC EFFECTS OF GLYCOSIDES OF CISTANCHE ON HEMORRHAGIC SHOCK/REPERFUSION INJURY IN ANIMAL EXPERIMENT |
| |
| Abstract: | Objective:To study the therapeutic effects of glycosides of cistanche on hemorrhagic shock/reperfusion injury(S/R).Methods:Changes of several parameters and effects of GC on it were observed with hemorrhagic shock/reperfusion injury (S/R) rabbit model, parameters of which included LPO,MDA,SOD,TXB 2 and 6-keto-PGF1.Results:LPO,MDA and TXB 2 increased significantly(P<0 01),SOD and 6-keto-PGF1α decreased significantly(P<0 01) in S/R group compared with sham group.With treatment of GC,the abnormal changes of all above parameters were diminished remarkably(P<0 05 and P<0 01).Conclusion:GC hasa therapeutic effect on hemorrhagic shock/reperfusion injury. |
| |
| Keywords: | glycosides of cistanche shock ischemia/reperfusion injury |
| 本文献已被 万方数据 等数据库收录！ |
|
