婴幼儿后颅凹肿瘤43例临床分析

目的 探讨婴幼儿后颅凹肿瘤的临床特点及治疗方法.方法 回顾性分析43例婴幼儿后颅凹肿瘤的临床资料.结果 婴幼儿后颅凹肿瘤的常见症状为呕吐和共济失调.43例中,肿瘤全切除32例(74.4%),近全切除8例(18.6%),大部切除3例(7.0%),本组无手术死亡.33例随访13个月～7年,其中术后放疗13例,12例存活,1例术后2年死亡;术后未放疗的20例患儿中,8例存活,12例于术后2个月～2年死亡.结论 显微镜下肿瘤全切除是良好预后的关键.恶性肿瘤单纯手术预后不好,术后分子病理学指导下的放化疗是今后治疗的方向.

The clinical features and treatment of tumors at posterior fossa in infants

Objective To explore the treatments of tumors at posterior fossa in infants. Methods Forty-three cases with tumors at posterior fossa of infants who were admitted and operated in recent 6 years in Tiantan hospital were retrospectively analyzed. Results The common symptoms of the tumors located at posterior fossa included vomiting and ataxia. Operation was the first choice. The total tumor rate of removal was 74.4%, subtotal removal rate was 18.6%, partial removal rate was 7.0%, no patient died. Thirty-three patients were followed up and 13 patients were treated by radiotherapy. Conclusions It is very important to remove the whole tumor, but for malignant tumor, good recovery can not be achieved by operation only. Although radiotherapy is one of ways to inhibit the growth of tumor, but it should be cautious for infants. Molecular pathology based on chemotherapy and radiotherapy may be the further strategy for treating malignant tumor in infants.