低温射频消融术治疗阻塞性睡眠呼吸暂停低通气综合征

目的:探讨低温射频消融术(temperature-controlled radiofrequency ablation,TCRF)治疗阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的疗效和手术前后生活质量的变化。方法:对50例OSAHS患者行TCRF治疗,比较治疗前后呼吸暂停低通气指数(apnea hypopnea index,AHI)、最低血氧饱和度(lowest arterial oxygeon saturation,LSaO2)、Epworth嗜睡评分(Epworth Sleepiness Scale,ESS)和Calgary生活质量指数(Calgary Sleep Apnea Quality of Life Index,SAQLI),从主、客观方面对TCRF治疗OSAHS进行疗效评价。结果:术后6个月复查多导睡眠监测(polysomnography,PSG),50例患者中总有效43例,其中治愈19例,显效18例,有效6例,无效7例,总有效率86.0%。手术前后AHI平均值分别为45.20+20.50和26.50+30.15,LSaO2平均值分别为0.70+0.24和0.83+0.10。Epworth嗜睡程度评分由术前9.4+5.2下降至术后4.0+3.3,SAQLI总分从术前3.9+1.0提高到术后4.7+1.1,差异均有统计学意义(P值均<0.05)。结论:TCRF是治疗OSAHS的有效方法,可提高OSAHS患者的生活质量。

Temperature-controlled radio-frequency ablation in treatment of obstructive sleep apnea hypopnea syndrome

Objective: To determine the efficacy of temperature-controlled radio-frequency ablation(TCFR) for obstructive sleep apnea hypopnea syndrome(OSAHS) in adult.Methods: Some objective and subjective indexes of fifty patients with OSAHS were determined before and after TCRF treatment.A full-night polysomnography examination was performed on all patients.The Epworth sleepiness scale(ESS) and the Calgary sleep apnea quality of life index(SAQLI) were assessed before and six months after operation.Results: Of them,19 cases were cured,18 cases were significantly improved,16 cases were improved,and 7 cases were not improved.The mean apnea hypopnea index(AHI) decreased from(45.2+20.5)/h to(26.5+30.2)/h and the mean lowest arterial oxygen saturation(LSaO2) increased from(0.7+0.1) to(0.8+0.1).The ESS decreased from(9.4+5.2) to(4.0+3.3) and the SAQLI increased from(3.8+1.0) to(4.8+1.1).All the above differences were significant(P<0.05).Conclusion: TCFR is an effective treatment for OSAHS and can improve the health-related quality of life.