Abstract: | A case of primary mucosa‐associated lymphoid tissue lymphoma (MALToma) occurring in the transverse colon is reported. Endoscopic examination revealed a flat and oval‐shaped submucosal tumor‐like lesion, approximately 2 cm in diameter in the transverse colon. The tumor extracted by laparotomy showed proliferation of centrocyte‐like cells positive for L26 immunostaining. The patient was diagnosed as having MALToma in the transverse colon. In this case, although the tumor invasion was limited to the submucosal layer, lymph node involvement was seen. Awareness of the clinical presentation and familiarization of colorectal MALToma are important. We emphasize that even if either antibiotic therapy or surgery is chosen for the therapy of colorectal MALToma, lymph node involvement should generally be taken into consideration, although the tumor invasion was limited to the submucosal layer. |