同步放化疗治疗宫颈癌的临床研究

目的评价中晚期宫颈癌综合治疗的远期疗效和并发症。方法回顾分析132例宫颈癌患者的临床资料、治疗方法、随访、复查以及复发转移等情况。结果5、7年生存率分别为72．7％、60．6％；无放射性膀胱炎发生，5年、7年放射性直肠炎发生率分别为9．4％，10．8％；直肠阴道瘘发生率分别为2％、3．8％；阴道挛缩发生率分别为8．7％、55．6％；局部复发率分别为12．1％、28．2％，盆腔淋巴结转移发生率分别为31．8％、50．0％；远处转移分别为21．2％、28．8％。结论放疗联合局部化疗的综合治疗能提高局控率，降低复发率，减少局部淋巴和远处转移率，有效提高长期生存率，且并发症的发生率较低。是一种简单、安全、较理想的中晚期宫颈癌的治疗方案，有临床推广价值。

The clinical study of the concurrent chemoradiation for cervical cancer

Objective To evaluate the long term effect and adverse event of the synthetic therapy for cervical cancer.Methods To study the clinical data,treatment of 132 patients with cervical cancer, by using retrospective analysis.Results 5-,7-years survival rates were 72.2%,60.6%,no radioactive cystits, 5-,7-years vaginal contracture were 48.7%,55.6%, 5-,7-years locally recrudescence were 12.1%,28.2%, 5-,7-years pelvic lymph node metastasis were 31.8%,50.0%, 5-,7-years distant metastasis were 21.2%,28.8%.Conclusion The synthetic therapy of radiotherapy combined with locally chemotherapy could well improve local control rate,reduce recrudescence rate,local lymph node metastasis rate and metastasis rate. Also, it could well improve long term survival rate, and its adverse event rate is lower. It is a simple,effective therapy for cervical cancer.