| 参麦注射液对鼠脑星形胶质细胞缺氧/复氧损伤的保护作用 |
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| 引用本文： | 邬力祥,言惠文,刘发益. 参麦注射液对鼠脑星形胶质细胞缺氧/复氧损伤的保护作用[J]. 中国现代医学杂志, 2002, 12(7): 3-5 |
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| 作者姓名： | 邬力祥 言惠文 刘发益 |
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| 作者单位： | 中南大学湘雅医学院生理学教研室,长沙,410078 |
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| 摘 要： | 观察参麦注射液对培养的鼠脑星形胶质细胞缺氧 /复氧 (H/R)损伤后一氧化氮 (NO)分泌的影响。方法 :培养鼠脑星形胶质细胞 ,以缺氧 /复氧为损伤因素 ,观察培养上清液中NO及乳酸脱氢酶 (LDH)的变化。结果 :H/R损伤后星形胶质细胞NO的分泌显著提高 ,LDH漏出量显著增多 ,参麦注射液能明显抑制H/R状态下星形胶质细胞分泌NO ,并降低LDH的漏出。结论 :在H/R损伤情况下 ,参麦注射液对鼠脑星形胶质细胞具有保护作用 ,其可能机制与其抑制NO分泌和稳定细胞膜有关
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| 关 键 词： | 星形胶质细胞 缺氧/复氧 参麦 一氧化氮 乳酸脱氢酶 |
| 修稿时间： | 2002-03-01 |
THE PROTECTIVE EFFECT OF SHENMAI INJECTION ON CULTURED RAT CEREBRAL ASTROCYTES DAMAGED BY HYPOXIA REOXYGENATION |
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| Wu Lixiang,Yan Huiwen,Liu Fayi. THE PROTECTIVE EFFECT OF SHENMAI INJECTION ON CULTURED RAT CEREBRAL ASTROCYTES DAMAGED BY HYPOXIA REOXYGENATION[J]. China Journal of Modern Medicine, 2002, 12(7): 3-5 |
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| Authors: | Wu Lixiang Yan Huiwen Liu Fayi |
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| Affiliation: | Wu Lixiang,Yan Huiwen,Liu Fayi Department of Physiology,Xiangya Medical College of Central South Unviersity,Changsha 410078 |
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| Abstract: | Objective:To investigate the effect of shenmai injection (SMI) on production of the nitric oxide (NO) in supernatant of cultured rat cortical astrocytes damaged by hypoxia reoxygenation (H/R).Methods:The neonatal rat cerebral astrocytes was cultured and was identified with monoclonal antibody of anti-glial fibrillary acidic protein.The changes in NO formation and LDH leakage were measured during astrocytes H/R.Result:It showed that H/R injury increased the production of NO and LDH leakage.The pretreatment with SMI could inhibit them.Conclusion:SMI had protective effects on astrocytes damaged by H/R.The mechanism might be related with its inhibition of NO production. |
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| Keywords: | Astrocyte Hypoxia/Reoxygenation Shenmai Nitric Oxide Lactate Dehydrogenase |
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