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| Esophageal epithelial surface in patients with gastroesophageal reflux disease： An electron microscopic study | |
| 引用本文： | Azumi T,Adachi K,Furuta K,Nakata S,Ohara S,Koshino K,Miki M,Morita T,Tanimura T,Ashizawa N,Kinoshita Y. Esophageal epithelial surface in patients with gastroesophageal reflux disease： An electron microscopic study[J]. World journal of gastroenterology : WJG, 2008, 14(37): 5712-5716. DOI: 10.3748/wjg.14.5712 |
| 作者姓名： | Azumi T Adachi K Furuta K Nakata S Ohara S Koshino K Miki M Morita T Tanimura T Ashizawa N Kinoshita Y |
| 基金项目： | Grants-in-Aid,from,Science,Research,from,the,Ministry,of,Education,Culture,Sports,Science,and,Technology,of,Japan(项目编号：19590724) |
| 摘 要： | A/M： To investigate the intercellular spaces between the most superficially located esophageal epithelial cells in patients with gastroesophageal reflux disease （GERD）. METHODS： Eighteen patients with erosive esophagitis, 10 patients with non-erosive reflux disease （NERD）, and 18 normal asymptomatic volunteers were enrolled. Biopsy specimens were obtained from the lower esophageal mucosa without ulcer or erosion. Scanning electron microscopy was employed to investigate the tightness of the superficial cellular attachment. RESULTS： The intercellular space between the most superficially located epithelial cells in patients with erosive esophagitis or NERD was not different from that in asymptomatic healthy individuals. CONCLUSION： Widened luminal intercellular spaces of esophageal superficial epithelium are not responsible for the induction of reflux symptoms in patients with GERD. |
| 关 键 词： | 食道 上皮面 胃食管反流疾病 电子显微镜研究 |
Esophageal epithelial surface in patients with gastroesophageal reflux disease: an electron microscopic study |
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| Azumi Takane,Adachi Kyoichi,Furuta Kenji,Nakata Shuji,Ohara Shunji,Koshino Kenji,Miki Masaharu,Morita Terumi,Tanimura Takashi,Ashizawa Nobuo,Kinoshita Yoshikazu. Esophageal epithelial surface in patients with gastroesophageal reflux disease: an electron microscopic study[J]. World journal of gastroenterology : WJG, 2008, 14(37): 5712-5716. DOI: 10.3748/wjg.14.5712 | |
| Authors: | Azumi Takane Adachi Kyoichi Furuta Kenji Nakata Shuji Ohara Shunji Koshino Kenji Miki Masaharu Morita Terumi Tanimura Takashi Ashizawa Nobuo Kinoshita Yoshikazu |
| Affiliation: | Second Department of Internal Medicine,Shimane University School of Medicine,Shimane 693-8501,Japan |
| Abstract: | AIM: To investigate the intercellular spaces between the most superficially located esophageal epithelial cells in patients with gastroesophageal reflux disease (GERD).METHODS: Eighteen patients with erosive esophagitis,10 patients with non-erosive reflux disease (NERD),and 18 normal asymptomatic volunteers were enrolled.Biopsy specimens were obtained from the lower esophageal mucosa without ulcer or erosion.Scanning electron microscopy was employed to investigate the tightness of the superficial cellular attachment.RESULTS: The intercellular space between the most superficially located epithelial cells in patients with erosive esophagitis or NERD was not different from that in asymptomatic healthy individuals.CONCLUSION: Widened luminal intercellular spaces of esophageal superficial epithelium are not responsible for the induction of reflux symptoms in patients with GERD. |
| Keywords: | Reflux esophagitis Non-erosive gastroesophageal reflux diseases Electron microscopy Questionnaire |
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