从分子水平研究补肾法对性早熟与衰老的调控规律

肾阴肾阳失衡是性早熟和衰老的病理基础，衰老是“生理性肾虚”，其阴阳失衡是以肾阳虚为主；性早熟的本质是阴虚火旺，其阴阳失调是以肾阴虚为主。由肾气盛衰主导的生长、发育、衰老过程中，主要涉及生长激素轴和性腺轴，性早熟惠儿可见这两轴的提前启动，表现为阴虚火旺；而衰老时是这两轴的率先衰退，表现为阳气虚损。分别采用温补肾阳方药以延缓衰老与滋阴泻火方药以抑制性早熟取得临床与实验的显著效果，通过以药测证，推测发病部位，证明性早熟或衰老，其病理损害是在下丘脑或更高中枢。

Study on the Regulative Rule of Reinforcing Shen Principle on Sexual Precocity and Senescence at the Molecular Level

The imbalance of Shen-yin and Shen-yang is a common pathological basis of sexual precocity and senescence. Senescence can be regarded as physiological Shen-deficiency, which is mainly the deficiency of Shen-Yang,while the essence of sexual precocity is hyperactivity of Fire due to Yin-deficiency, and deficiency of Shen-Yin is the predominance in the imbalance. The process of growth, development, maturing and aging led by Shen-qi, is mainly involving the hypothalamus-pituitary-growth hormone axis and sexual gland axis. Early initiation of these two axes appears in sexual premature children, manifesting syndrome of Fire hyperactivity due to Yin-deficiency, while in senescence, the decline of the axes appears ahead of time and manifests syndrome of Yang qi consumption. It has been shown in experimental and clinical researches that significantly good effects could be obtained by applying Chinese recipe for warmly reinforcing Shen-Yang to postpone senescence and recipe for nourishing Yin and removing Fire to inhibit sexual precocity. It also been proved by determining syndrome and speculating the damaged site according to the effects of drug that the pathologic damage of sexual precocity and senescence is sited on the hypothalamus or higher center.