Expression of IGF-I and IGF-II mRNA in breast tissue |
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Authors: | Soonmyoung Paik MD |
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Institution: | (1) Department of Pathology, Lombardi Cancer Center, Georgetown University, Washington DC, USA |
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Abstract: | Summary Expression of IGF-I and IGF-II was studied in human breast cancer tissues by in situ hybridization. IGF-I mRNA was detected only in stromal cells adjacent to normal breast epithelial cells. Stromal cells associated with the tumor cells did not contain IGF-I, nor did malignant or benign breast epithelial cells. In contrast, IGF-II mRNA was found in both the malignant epithelial cells and their adjacent stromal cells. These data imply that stromal cells associated with breast epithelium may switch expression from IGF-I to IGF-II during breast cancer evolution. This appearance of IGF-II expression may identify cancer-associated stromal cells that have a fetal phenotype. |
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Keywords: | breast tumor cells epithelial cells IGF-I IGF-II in-situ hybridization insulin-like growth factors messenger RNA stromal cells |
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