白癜风患者应激生活事件及常见应激障碍调查

 目的  对白癜风患者发病前或复发前应激生活事件发生情况以及患病后伴发的常见应激障碍进行调查与评价。方法  采用病例对照方法,对55例白癜风患者（病例组）和118例健康者（对照组）进行流行病学调查与评价。应激生活事件调查采用杨德森生活事件量表(life event scale,LES);焦虑及抑郁评定分别采用汉密顿焦虑量表(Hamilton anxiety scale,HAMA)14项版本和汉密顿抑郁量表(Hamilton depression scale,HAMD)24项版本。结果  发病前或复发前1年内,病例组社交和其他方面总事件或负性事件数量低于正常对照组(P<0.05),而家庭方面、工作学习方面总事件以及总生活事件数量在两组间差异无统计学意义(P>0.05);工作学习方面总事件及负性事件评分、总生活事件与总负性生活事件评分均值、工作学习方面总事件与负性事件评分均值,病例组均高于正常对照组(P<0.05);焦虑和抑郁评分及发生率比较,病例组均高于正常对照组(P<0.05)。结论 白癜风患者可能存在较高的应激损伤易感性,并在白癜风发病及病情复发中发挥作用;白癜风患者常见应激障碍的发生率及严重程度高于健康者,应激障碍与白癜风密切相关。

Investigation of stress events and stress disorders in patients with vitiligo

Objective  To investigate the stress events before onset or recurrence of disease and to evaluate the common stress disorders such as anxiety or depression in patients with vitiligo.Methods  Case control study was carried out in 55 patients as the case group and 118 healthys as the control group.Yangdesen′s life event scale (LES) was applied for stress events investigation.Hamilton anxiety scale (HAMA,14 item version) was applied for anxiety evaluation as well as Hamilton depression scale (HAMD,24 item version) for depression evaluation.Results  One year before onset or recurrence,the number of stress events in the case group were not more than that in the control group.However,the score of total events and negative events about working and learning,the mean score of total events and negative events,the mean score of total events and negative events about working and learning in case group increased significantly compared with that in control group (P<0.05).The incidence and the score of anxiety or depression in case group also increased significantly compared with that in control group (P<0.05).Conclusions  There may exist increased susceptibility to vitiligo in patients after stressful life events which may play an important role on onset and reccurence of vitiligo.Incidence and severity of accompanied stress disorders are higher in vitiligo,and stress disorders are closely related to vitiligo.